Co-Target(s) Information
| Target General Information | Top | ||||
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| Target ID | T51115 | Target Info | |||
| Target Name | Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) | ||||
| Synonyms |
Voltage-gated calcium channel subunit alpha Cav1.2; Voltage-dependent L-type calcium channel subunit alpha-1C; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; CCHL1A1; CACNL1A1; CACN2; CACH2
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| Target Type | Successful Target | ||||
| Gene Name | CACNA1C | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Debrisoquine 4-hydroxylase (CYP2D6) | Successful Target | ||||
| UniProt ID | CP2D6_HUMAN | |||||
| Gene Name | CYP2D6 | |||||
| Synonyms |
P450-DB1; Cytochrome P450-DB1; Cytochrome P450 2D6; CYPIID6; CYP2DL1
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| Representative Drug(s) | Drug Info | Ki = 3.3 nM | [1] | |||
| Co-Target Name | Adrenergic receptor alpha-2C (ADRA2C) | Successful Target | ||||
| UniProt ID | ADA2C_HUMAN | |||||
| Gene Name | ADRA2C | |||||
| Synonyms |
Subtype C4; Alpha-2CAR; Alpha-2C adrenoreceptor; Alpha-2C adrenoceptor; Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptor subtype C4; ADRA2RL2; ADRA2L2
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| Representative Drug(s) | Drug Info | Ki = 5 nM | [2] | |||
| Co-Target Name | Adrenergic receptor alpha-2A (ADRA2A) | Successful Target | ||||
| UniProt ID | ADA2A_HUMAN | |||||
| Gene Name | ADRA2A | |||||
| Synonyms |
Alpha-2AAR; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptor subtype C10; ADRAR; ADRA2R
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| Representative Drug(s) | Drug Info | Ki = 8.2 nM | [2] | |||
| Co-Target Name | Adrenergic receptor alpha-2B (ADRA2B) | Successful Target | ||||
| UniProt ID | ADA2B_HUMAN | |||||
| Gene Name | ADRA2B | |||||
| Synonyms |
Subtype C2; Alpha-2BAR; Alpha-2B adrenoreceptor; Alpha-2B adrenoceptor; Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptor subtype C2; ADRA2RL1; ADRA2L1
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| Representative Drug(s) | Drug Info | Ki = 14.5 nM | [2] | |||
| Co-Target Name | Human immunodeficiency virus Reverse transcriptase (HIV RT) | Successful Target | ||||
| UniProt ID | POL_HV1B1 | |||||
| Gene Name | HIV RT | |||||
| Synonyms |
HIV p66 RT; HIV Exoribonuclease H
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| Representative Drug(s) | Drug Info | IC50 ~ 200 ug.mL-1 | [3] | |||
| Co-Target Name | Pregnane X receptor (NR1I2) | Literature-reported Target | ||||
| UniProt ID | NR1I2_HUMAN | |||||
| Gene Name | NR1I2 | |||||
| Synonyms |
Steroid and xenobiotic receptor; SXR; PXR; Orphan nuclear receptor PXR; Orphan nuclear receptor PAR1; Nuclear receptor subfamily 1 group I member 2
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| Representative Drug(s) | ARC029 | Drug Info | EC50 = 890 nM | [4] | ||
| References | Top | ||||
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| REF 1 | Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies. J Med Chem. 1993 Apr 30;36(9):1136-45. | ||||
| REF 2 | Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. | ||||
| REF 3 | Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. J Nat Prod. 1991 Jan-Feb;54(1):143-54. | ||||
| REF 4 | Identification of clinically used drugs that activate pregnane X receptors. Drug Metab Dispos. 2011 Jan;39(1):151-9. | ||||
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