Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T52790 Target Info
Target Name Substance-K receptor (TACR2)
Synonyms
Tachykinin receptor 2; Tachykinin neurokinin 2 receptor; TACR2; SKR; Neurokinin A receptor; NK-2R; NK-2 receptor
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Target Type Clinical trial Target
Gene Name TACR2
Biochemical Class GPCR rhodopsin
UniProt ID
NK2R_HUMAN
Co-Targets of This Target  Top
Co-Target Name Melanocortin receptor 4 (MC4R) Successful Target
UniProt ID MC4R_HUMAN
Gene Name MC4R
Synonyms
MC4-R
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Representative Drug(s) PMX-53 Drug Info IC50 = 400 nM [1]
Co-Target Name Vasopressin V1a receptor (V1AR) Successful Target
UniProt ID V1AR_HUMAN
Gene Name AVPR1A
Synonyms
Vascular/hepatic-type arginine vasopressin receptor; V1aR; V1a vasopressin receptor; Antidiuretic hormone receptor 1a; AVPR1; AVPR V1a
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Representative Drug(s) PMX-53 Drug Info IC50 = 740 nM [1]
Co-Target Name Cytochrome P450 26 (CYP26A1) Clinical trial Target
UniProt ID CP26A_HUMAN
Gene Name CYP26A1
Synonyms
Retinoic acid-metabolizing cytochrome; Retinoic acid inducible enzyme; Retinoic acid 4-hydroxylase; P450RAI; P450 retinoic acid-inactivating 1; HP450RAI; Cytochrome P450RAI; CYP26A1
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Representative Drug(s) Rambazole Drug Info IC50 = 5.1 nM [2]
Co-Target Name C5a anaphylatoxin chemotactic receptor (C5AR1) Successful Target
UniProt ID C5AR1_HUMAN
Gene Name C5AR1
Synonyms
CD88; C5aR; C5a-R; C5a anaphylatoxin chemotactic receptor 1; C5R1
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Representative Drug(s) PMX-53 Drug Info IC50 = 15 nM [3]
Co-Target Name Cytochrome P450 26B1 (CYP26B1) Co-Target
UniProt ID CP26B_HUMAN
Gene Name CYP26B1
Synonyms
Cytochrome P450 26A2; Cytochrome P450 retinoic acid-inactivating 2; Cytochrome P450RAI-2; Retinoic acid-metabolizing cytochrome
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Representative Drug(s) Rambazole Drug Info IC50 = 0.46 nM [2]
References  Top
REF 1 Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5088-92.
REF 2 Development and Characterization of Novel and Selective Inhibitors of Cytochrome P450 CYP26A1, the Human Liver Retinoic Acid Hydroxylase. J Med Chem. 2016 Mar 24;59(6):2579-95.
REF 3 Selective hexapeptide agonists and antagonists for human complement C3a receptor. J Med Chem. 2010 Jul 8;53(13):4938-48.

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