Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T56556 Target Info
Target Name ATP-binding cassette transporter G2 (ABCG2)
Synonyms
Urate exporter; Placenta-specific ATP-binding cassette transporter; Mitoxantrone resistance-associated protein; MXR; CDw338; CD338; Breast cancer resistance protein; BCRP1; BCRP; ABCP
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Target Type Successful Target
Gene Name ABCG2
Biochemical Class ABC transporter
UniProt ID
ABCG2_HUMAN
Co-Targets of This Target  Top
Co-Target Name Cystine/glutamate transporter (SLC7A11) Literature-reported Target
UniProt ID XCT_HUMAN
Gene Name SLC7A11
Synonyms
XCT; X(c)-cystine transporter; X(c)- plasma membrane cystine transporter; Solute carrier family 7 member 11; Calcium channel blocker resistance protein CCBR1; Amino acid transport system xc-; Amino acid transport system XCT
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Representative Drug(s) Sulfasalazine Drug Info IC50 = 160 nM [1]
Co-Target Name Liver organic anion transporter 1 (SLCO1B1) Literature-reported Target
UniProt ID SO1B1_HUMAN
Gene Name SLCO1B1
Synonyms
Solute carrier organic anion transporter family member 1B1; Solute carrier family 21 member 6; Sodium-independent organic anion-transporting polypeptide 2; SLC21A6; OATPC; OATP2; OATP-C; OATP-2; Liver-specific organic anion transporter 1; LST1; LST-1
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Representative Drug(s) Sulfasalazine Drug Info Ki = 530 nM [2]
References  Top
REF 1 Discovery and development of small molecule modulators targeting glutamine metabolism. Eur J Med Chem. 2019 Feb 1;163:215-242.
REF 2 Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. J Med Chem. 2012 May 24;55(10):4740-63.

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