Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T66505 | Target Info | |||
| Target Name | Smoothened homolog (SMO) | ||||
| Synonyms |
Smo-D473H; SMOH; Protein Gx
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| Target Type | Successful Target | ||||
| Gene Name | SMO | ||||
| Biochemical Class | GPCR frizzled | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Hedgehog protein (SHH) | Literature-reported Target | ||||
| UniProt ID | SHH_HUMAN | |||||
| Gene Name | SHH | |||||
| Synonyms |
Sonic hedgehog protein C-product; Sonic hedgehog protein; SHH; HHG-1
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| Representative Drug(s) | Vismodegib | Drug Info | IC50 = 15 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification, characterization, and implications of species-dependent plasma protein binding for the oral Hedgehog pathway inhibitor vismodegib (GDC-0449). J Med Chem. 2011 Apr 28;54(8):2592-601. | ||||
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