Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T68536 Target Info
Target Name Tubulin beta (TUBB)
Synonyms
Major cysteine proteinase; Cysteine proteinase cruzipain; Cruzaine; Congopain; Beta-tubulin
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Target Type Successful Target
Gene Name NO-GeName
Biochemical Class Tubulin family
UniProt ID
NOUNIPROTAC
Co-Targets of This Target  Top
Co-Target Name Human immunodeficiency virus Reverse transcriptase (HIV RT) Successful Target
UniProt ID POL_HV1B1
Gene Name HIV RT
Synonyms
HIV p66 RT; HIV Exoribonuclease H
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Representative Drug(s) Vincristine Drug Info IC50 ~ 200 ug.mL-1 Click to Show More [1]
2 Taxol Drug Info IC50 ~ 200 ug.mL-1 [1]
Co-Target Name S-mephenytoin 4-hydroxylase (CYP2C9) Successful Target
UniProt ID CP2C9_HUMAN
Gene Name CYP2C9
Synonyms
Cytochrome P450 PB-1; Cytochrome P450 MP-8; Cytochrome P450 MP-4; Cytochrome P450 2C9; Cytochrome P-450MP; Cholesterol 25-hydroxylase; CYPIIC9; CYP2C10; (S)-limonene 7-monooxygenase; (S)-limonene 6-monooxygenase; (R)-limonene 6-monooxygenase
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Representative Drug(s) Drug Info IC50 = 530 nM [2]
Co-Target Name Integrin alpha-V/beta-3 (ITGAV/B3) Clinical trial Target
UniProt ID ITAV_HUMAN-ITB3_HUMAN
Gene Name ITGAV-ITGB3
Synonyms
Integrin alphaVbeta3; Integrin alpha-v beta-3; Integrin alpha V beta 3; Alpha(v)beta(3) Integrin; Alpha v beta 3 integrin
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Representative Drug(s) Taxol Drug Info IC50 = 34 nM [3]
Co-Target Name Liver organic anion transporter 2 (SLCO1B3) Literature-reported Target
UniProt ID SO1B3_HUMAN
Gene Name SLCO1B3
Synonyms
Solute carrier organic anion transporter family member 1B3; Solute carrier family 21 member 8; SLC21A8; Organic anion-transporting polypeptide 8; Organic anion transporter 8; OATP8; OATP1B3; OATP-8; Liver-specific organic anion transporter 2; LST2; LST-2
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Representative Drug(s) Taxol Drug Info IC50 = 260 nM [4]
Co-Target Name Liver organic anion transporter 1 (SLCO1B1) Literature-reported Target
UniProt ID SO1B1_HUMAN
Gene Name SLCO1B1
Synonyms
Solute carrier organic anion transporter family member 1B1; Solute carrier family 21 member 6; Sodium-independent organic anion-transporting polypeptide 2; SLC21A6; OATPC; OATP2; OATP-C; OATP-2; Liver-specific organic anion transporter 1; LST1; LST-1
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Representative Drug(s) Taxol Drug Info IC50 = 280 nM [4]
Co-Target Name Tubulin beta-3 chain (TUBB3) Co-Target
UniProt ID TBB3_HUMAN
Gene Name TUBB3
Synonyms
Tubulin beta-4 chain; Tubulin beta-III
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Representative Drug(s) Taxol Drug Info IC50 = 7.7 nM [5]
References  Top
REF 1 Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. J Nat Prod. 1991 Jan-Feb;54(1):143-54.
REF 2 In vitro and in vivo pharmacokinetic and pharmacodynamic study of MBRI-001, a deuterium-substituted plinabulin derivative as a potent anti-cancer agent. Bioorg Med Chem. 2018 Sep 1;26(16):4687-4692.
REF 3 Synthesis and biological evaluation of dimeric RGD peptide-paclitaxel conjugate as a model for integrin-targeted drug delivery. J Med Chem. 2005 Feb 24;48(4):1098-106.
REF 4 Interaction of human organic anion transporter polypeptides 1B1 and 1B3 with antineoplastic compounds. Eur J Med Chem. 2015 Mar 6;92:723-31.
REF 5 Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents. J Med Chem. 2013 Sep 12;56(17):6829-44.

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