Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T70967 | Target Info | |||
| Target Name | Neuronal acetylcholine receptor alpha-4 (CHRNA4) | ||||
| Synonyms |
Nicotinic acetylcholine receptor alpha4; CHRNA4; Alpha-4 nAChR
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| Target Type | Successful Target | ||||
| Gene Name | CHRNA4 | ||||
| Biochemical Class | Neurotransmitter receptor | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Neuronal acetylcholine receptor alpha-3/beta-4 (CHRNA3/B4) | Successful Target | ||||
| UniProt ID | ACHA3_HUMAN-ACHB4_HUMAN | |||||
| Gene Name | CHRNA3-CHRNB4 | |||||
| Synonyms |
Neuronal acetylcholine receptor
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| Representative Drug(s) | CYTISINE | Drug Info | Ki = 280 nM | [1] | ||
| Co-Target Name | Acetylcholine receptor alpha-1/beta-1/delta/gamma (CHRNA1/CHRNA1/CHRND/CHRNG) | Co-Target | ||||
| UniProt ID | ACHA_HUMAN-ACHB_HUMAN-ACHD_HUMAN-ACHG_HUMAN | |||||
| Gene Name | CHRNA1-CHRNB1-CHRND-CHRNG | |||||
| Representative Drug(s) | CYTISINE | Drug Info | EC50 = 11 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | (+)-Laburnamine, a natural selective ligand and partial agonist for the alpha42 nicotinic receptor subtype. J Nat Prod. 2013 Apr 26;76(4):727-31. | ||||
| REF 2 | Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1221-4. | ||||
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