Co-Target(s) Information

Content Navigation (  All   None )                                      
Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T73756 Target Info
Target Name Ephrin type-B receptor 2 (EPHB2)
Synonyms
hEK5; Tyrosine-protein kinase receptor EPH-3; Tyrosine-protein kinase TYRO5; TYRO5; Renal carcinoma antigen NY-REN-47; Receptor protein-tyrosine kinase HEK5; EphB2 receptor tyrosine kinase; EphB2; EPTH3; EPHT3; EPH-like kinase 5; EPH tyrosine kinase 3; ELK-related tyrosine kinase; EK5; Developmentally-regulated Eph-related tyrosine kinase; DRT
    Click to Show/Hide
Target Type Clinical trial Target
Gene Name EPHB2
Biochemical Class Kinase
UniProt ID
EPHB2_HUMAN
Co-Targets of This Target  Top
Co-Target Name Extracellular signal-regulated kinase 2 (ERK2) Clinical trial Target
UniProt ID MK01_HUMAN
Gene Name MAPK1
Synonyms
PRKM2; PRKM1; P42-MAPK; P42 Mitogen-activated protein kinase; Mitogen-activated protein kinase 2; Mitogen-activated protein kinase 1; MAPK 2; MAPK 1; MAP kinase isoform p42; MAP kinase 2; MAP kinase 1; ERT1; ERK-2
    Click to Show/Hide
Representative Drug(s) BVD-523 Drug Info IC50 = 0.03 nM Click to Show More [1]
2 MK-8353 Drug Info IC50 = 7 nM [2]
Co-Target Name Extracellular signal-regulated kinase 1 (ERK1) Clinical trial Target
UniProt ID MK03_HUMAN
Gene Name MAPK3
Synonyms
PRKM3; P44-MAPK; P44-ERK1; P44 Mitogen-activated protein kinase; Mitogen-activated protein kinase 3; Microtubule-associated protein-2 kinase; Microtubule-associated protein 2 kinase; MAPK 3; MAP kinase isoform p44; MAP kinase 3; Insulin-stimulated MAP2 kinase; ERT2; ERK-1
    Click to Show/Hide
Representative Drug(s) MK-8353 Drug Info IC50 = 20 nM [2]
Co-Target Name Mitogen-activated protein kinase 1 (MAPK1) Co-Target
UniProt ID MK01_HUMAN
Gene Name MAPK1
Synonyms
MAP kinase 1; MAPK 1; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2
    Click to Show/Hide
Representative Drug(s) BVD-523 Drug Info IC50 = 140 nM [3]
Co-Target Name Mitogen-activated protein kinase 3 (MAPK3) Co-Target
UniProt ID MK03_HUMAN
Gene Name MAPK3
Synonyms
MAP kinase 3; MAPK 3; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1
    Click to Show/Hide
Representative Drug(s) BVD-523 Drug Info IC50 = 140 nM [3]
References  Top
REF 1 Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3788-92.
REF 2 MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology. ACS Med Chem Lett. 2018 Jun 14;9(7):761-7.
REF 3 Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2. J Med Chem. 2015 Jun 11;58(11):4790-801.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.