Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T75498 Target Info
Target Name Quinone reductase 2 (NQO2)
Synonyms
Quinone oxidoreductase 2; Qui reductase 2; QR2; NRH:quinone oxidoreductase 2; NRH:qui oxidoreductase 2; NQO2; NAD(P)H qui oxidoreductase 2
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Target Type Successful Target
Gene Name NQO2
Biochemical Class Diphenol donor oxidoreductase
UniProt ID
NQO2_HUMAN
Co-Targets of This Target  Top
Co-Target Name Melatonin receptor type 1A (MTNR1A) Successful Target
UniProt ID MTR1A_HUMAN
Gene Name MTNR1A
Synonyms
Mel1a receptor; Mel1AR; Mel-1A-R
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Representative Drug(s) Melatonin Drug Info EC50 = 0.0257 nM [1]
Co-Target Name Melatonin receptor type 1B (MTNR1B) Successful Target
UniProt ID MTR1B_HUMAN
Gene Name MTNR1B
Synonyms
Mel1b receptor; Mel1b melatonin receptor; Mel-1B-R
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Representative Drug(s) Melatonin Drug Info EC50 = 0.069 nM [2]
Co-Target Name Histamine H3 receptor (H3R) Clinical trial Target
UniProt ID HRH3_HUMAN
Gene Name HRH3
Synonyms
Histamine receptor 3; HH3R; GPCR97; G-protein coupled receptor 97; G protein-coupled receptor 97
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Representative Drug(s) Melatonin Drug Info Ki = 0.5 nM [3]
References  Top
REF 1 1,6-Dihydro-2H-indeno[5,4-b]furan derivatives: design, synthesis, and pharmacological characterization of a novel class of highly potent MT selective agonists. J Med Chem. 2011 May 12;54(9):3436-44.
REF 2 Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential. J Med Chem. 2015 Jun 25;58(12):4998-5014.
REF 3 New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H 3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition. J Med Chem. 2019 Dec 26;62(24):11416-11422.

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