Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T78111 Target Info
Target Name Nicotinic acetylcholine receptor (nAChR)
Synonyms
nAChR; Nicotinergic acetylcholine receptor
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Target Type Successful Target
Gene Name NO-GeName
Biochemical Class Ion transport
UniProt ID
NOUNIPROTAC
Co-Targets of This Target  Top
Co-Target Name Neuronal acetylcholine receptor alpha-7 (CHRNA7) Successful Target
UniProt ID ACHA7_HUMAN
Gene Name CHRNA7
Synonyms
Nicotinic acetylcholine receptor subunit alpha 7; Nicotinic acetylcholine receptor alpha7; CHRNA7; Alpha7 nicotinic receptor; Alpha7 nAChR; Alpha-7 nAChR; Alpha(7) nicotinic receptor
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Representative Drug(s) Drug Info Ki = 148 nM Click to Show More [1]
2 Nicotine Drug Info Ki = 620 nM [2]
Co-Target Name Neuronal acetylcholine receptor alpha-3 (CHRNA3) Co-Target
UniProt ID ACHA3_HUMAN
Gene Name CHRNA3
Synonyms
Neuronal acetylcholine receptor subunit alpha-3
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Representative Drug(s) Nicotine Drug Info IC50 = 45 nM Click to Show More [3]
2 Drug Info EC50 = 700 nM [1]
References  Top
REF 1 Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. J Med Chem. 1998 Feb 12;41(4):407-12.
REF 2 Molecular recognition in nicotinic acetylcholine receptors: the importance of pi-cation interactions. J Med Chem. 1999 Aug 12;42(16):3066-74.
REF 3 Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors. J Agric Food Chem. 2000 Dec;48(12):6016-24.

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