Co-Target(s) Information

Content Navigation (  All   None )                                      
Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T78932 Target Info
Target Name TYK2 tyrosine kinase (TYK2)
Synonyms
Non-receptor tyrosine-protein kinase TYK2
    Click to Show/Hide
Target Type Successful Target
Gene Name TYK2
Biochemical Class Kinase
UniProt ID
TYK2_HUMAN
Co-Targets of This Target  Top
Co-Target Name Janus kinase 1 (JAK-1) Successful Target
UniProt ID JAK1_HUMAN
Gene Name JAK1
Synonyms
Tyrosine-protein kinase JAK1; JAK1B; JAK1A
    Click to Show/Hide
Representative Drug(s) Deucravacitinib Drug Info IC50 = 1 nM [1]
Co-Target Name Bone morphogenetic protein receptor (BMPR2) Literature-reported Target
UniProt ID BMPR2_HUMAN
Gene Name BMPR2
Synonyms
PPH1; Bone morphogenetic protein receptor type-2; Bone morphogenetic protein receptor type II; BMPR-II; BMPR-2; BMP type-2 receptor; BMP type II receptor
    Click to Show/Hide
Representative Drug(s) Deucravacitinib Drug Info IC50 = 193 nM [1]
Co-Target Name Tyrosine protein kinase JAK1-Tyrosine protein kinase JAK3 complex (JAK1-JAK3) Co-Target
UniProt ID JAK3_HUMAN-JAK1_HUMAN
Gene Name JAK1-JAK3
Representative Drug(s) Deucravacitinib Drug Info IC50 = 592 nM [1]
Co-Target Name Tyrosine protein kinase JAK1-Tyrosine protein kinase JAK2 complex (JAK1-JAK2) Co-Target
UniProt ID JAK1_HUMAN-JAK2_HUMAN
Gene Name JAK2-JAK1
Representative Drug(s) Deucravacitinib Drug Info IC50 = 609 nM [1]
References  Top
REF 1 Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J Med Chem. 2019 Oct 24;62(20):8973-8995.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.