Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T82266 | Target Info | |||
| Target Name | Voltage-gated L-type calcium channel (L-CaC) | ||||
| Synonyms |
L-type voltage-dependent Ca(2+) channel; L-type Ca2+ channel; L-type Ca(2+) channel
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| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Aldose reductase (AKR1B1) | Successful Target | ||||
| UniProt ID | ALDR_HUMAN | |||||
| Gene Name | AKR1B1 | |||||
| Synonyms |
Aldehyde reductase; AKR1B1
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| Representative Drug(s) | Epalrestat | Drug Info | IC50 = 0.03 ug.mL-1 | [1] | ||
| Co-Target Name | Aldo-keto reductase family 1 member B10 (AKR1B10) | Co-Target | ||||
| UniProt ID | AK1BA_HUMAN | |||||
| Gene Name | AKR1B10 | |||||
| Synonyms |
ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase
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| Representative Drug(s) | Epalrestat | Drug Info | IC50 = 330 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structures and aldose reductase inhibitory effects of bromophenols from the red alga Symphyocladia latiuscula. J Nat Prod. 2005 Apr;68(4):620-2. | ||||
| REF 2 | Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10. Bioorg Med Chem. 2010 Apr 1;18(7):2485-90. | ||||
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