Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T82577 Target Info
Target Name Angiotensin-converting enzyme (ACE)
Synonyms
Kininase II; Dipeptidyl carboxypeptidase I; DCP1; DCP; CD143 antigen; CD143; ACE
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Target Type Successful Target
Gene Name SLC33A1
Biochemical Class Glycosylase
UniProt ID
ACE_HUMAN
Co-Targets of This Target  Top
Co-Target Name Angiotensinogenase renin (REN) Successful Target
UniProt ID RENI_HUMAN
Gene Name REN
Synonyms
Renin; Angiotensinogenase
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Representative Drug(s) Captopril Drug Info Ki = 1.7 nM [1]
Co-Target Name Voltage-gated L-type calcium channel (L-CaC) Successful Target
UniProt ID CAC1C_HUMAN; CAC1D_HUMAN; CAC1F_HUMAN; CAC1S_HUMAN
Gene Name NO-GeName
Synonyms
L-type voltage-dependent Ca(2+) channel; L-type Ca2+ channel; L-type Ca(2+) channel
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Representative Drug(s) Gallopamil Drug Info Ki = 5.4 nM [2]
Co-Target Name Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) Successful Target
UniProt ID CAC1C_HUMAN
Gene Name CACNA1C
Synonyms
Voltage-gated calcium channel subunit alpha Cav1.2; Voltage-dependent L-type calcium channel subunit alpha-1C; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; CCHL1A1; CACNL1A1; CACN2; CACH2
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Representative Drug(s) Gallopamil Drug Info IC50 = 17 nM [3]
Co-Target Name Coagulation factor IIa (F2) Successful Target
UniProt ID THRB_HUMAN
Gene Name F2
Synonyms
Prothrombin; Coagulation factor II
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Representative Drug(s) Captopril Drug Info Ki = 48 nM [4]
Co-Target Name Carbonic anhydrase XII (CA-XII) Successful Target
UniProt ID CAH12_HUMAN
Gene Name CA12
Synonyms
Tumor antigen HOM-RCC-3.1.3; Carbonic anhydrase 12; Carbonate dehydratase XII
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Representative Drug(s) CONTIGOSIDE B Drug Info Ki = 52.1 nM [5]
Co-Target Name Leukotriene A-4 hydrolase (LTA4H) Successful Target
UniProt ID LKHA4_HUMAN
Gene Name LTA4H
Synonyms
Leukotriene A4 hydrolase; Leukotriene A(4)Leukotriene A-4 hydrolase hydrolase; Leukotriene A(4) hydrolase; LTA4; LTA-H; LTA-4hydrolase; LTA-4 hydrolase
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Representative Drug(s) Captopril Drug Info IC50 = 70 nM [6]
Co-Target Name Carbonic anhydrase IV (CA-IV) Successful Target
UniProt ID CAH4_HUMAN
Gene Name CA4
Synonyms
Carbonic anhydrase 4; Carbonate dehydratase IV; CAIV
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Representative Drug(s) CONTIGOSIDE B Drug Info Ki = 75.7 nM [5]
Co-Target Name Human immunodeficiency virus Reverse transcriptase (HIV RT) Successful Target
UniProt ID POL_HV1B1
Gene Name HIV RT
Synonyms
HIV p66 RT; HIV Exoribonuclease H
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Representative Drug(s) Deserpidine Drug Info IC50 ~ 200 ug.mL-1 [7]
Co-Target Name Carbonic anhydrase II (CA-II) Successful Target
UniProt ID CAH2_HUMAN
Gene Name CA2
Synonyms
Carbonic anhydrase C; Carbonic anhydrase 2; Carbonate dehydratase II; CAC
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Representative Drug(s) Drug Info Ki = 290 nM Click to Show More [8]
2 CONTIGOSIDE B Drug Info Ki = 410 nM [5]
Co-Target Name Carbonic anhydrase I (CA-I) Successful Target
UniProt ID CAH1_HUMAN
Gene Name CA1
Synonyms
Carbonic anhydrase B; Carbonic anhydrase 1; Carbonate dehydratase I; CAB
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Representative Drug(s) Drug Info Ki = 328 nM [9]
Co-Target Name Lysine-specific histone demethylase 1 (LSD) Clinical trial Target
UniProt ID KDM1A_HUMAN
Gene Name KDM1A
Synonyms
Lysine-specific histone demethylase 1A; LSD1; KIAA0601; KDM1; Flavin-containing amine oxidase domain-containing protein 2; BRAF35-HDAC complex protein BHC110; AOF2
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Representative Drug(s) CONTIGOSIDE B Drug Info IC50 = 950 nM [10]
Co-Target Name Carbonic anhydrase VII (CA-VII) Patented-recorded Target
UniProt ID CAH7_HUMAN
Gene Name CA7
Synonyms
Carbonic anhydrase 7; Carbonate dehydratase VII
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Representative Drug(s) CONTIGOSIDE B Drug Info Ki = 3.8 nM [5]
References  Top
REF 1 Inhibition of the renin-angiotensin system. A new approach to the therapy of hypertension. J Med Chem. 1981 Apr;24(4):355-61.
REF 2 Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds. Eur J Med Chem. 2013 May;63:85-94.
REF 3 Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. J Appl Toxicol. 2012 Oct;32(10):858-66.
REF 4 Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3727-31.
REF 5 New natural product carbonic anhydrase inhibitors incorporating phenol moieties. Bioorg Med Chem. 2015 Nov 15;23(22):7219-25.
REF 6 Probing the inhibition of leukotriene A4 hydrolase based on its aminopeptidase activity. Bioorg Med Chem Lett. 1991;1(10):551-6.
REF 7 Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. J Nat Prod. 1991 Jan-Feb;54(1):143-54.
REF 8 The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides. Bioorg Med Chem. 2013 Mar 15;21(6):1534-8.
REF 9 Sulfonamide inhibition studies of the eta-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum. Bioorg Med Chem. 2015 Feb 1;23(3):526-31.
REF 10 Flavone-based natural product agents as new lysine-specific demethylase 1 inhibitors exhibiting cytotoxicity against breast cancer cells in vitro. Bioorg Med Chem. 2019 Jan 15;27(2):370-374.

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