Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T85421 | Target Info | |||
| Target Name | Jun N terminal kinase (JNK) | ||||
| Synonyms |
c-Jun N-terminal kinase; Stress-activated protein kinase JNK; SAPK1; PRKM; MAP kinase; JNK
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| Target Type | Clinical trial Target | ||||
| Gene Name | MAPK8; MAPK9; MAPK10 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Epidermal growth factor receptor (EGFR) | Successful Target | ||||
| UniProt ID | EGFR_HUMAN | |||||
| Gene Name | EGFR | |||||
| Synonyms |
Receptor tyrosine-protein kinase erbB-1; Proto-oncogene c-ErbB-1; HER1; ERBB1; ERBB
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| Representative Drug(s) | Drug Info | IC50 = 380 nM | [1] | |||
| Co-Target Name | Stress-activated protein kinase JNK1 (JNK1) | Clinical trial Target | ||||
| UniProt ID | MK08_HUMAN | |||||
| Gene Name | MAPK8 | |||||
| Synonyms |
Stress-activated protein kinase 1c; SAPK1c; PRKM8; Mitogen-activated protein kinase 8; MAPK 8; MAP kinase 8; JNK-46; C-Jun N-terminal kinase 1
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| Representative Drug(s) | Drug Info | Ki = 44 nM | [1] | |||
| Co-Target Name | Maternal embryonic leucine zipper kinase (MELK) | Clinical trial Target | ||||
| UniProt ID | MELK_HUMAN | |||||
| Gene Name | MELK | |||||
| Synonyms |
Protein kinase PK38; Protein kinase Eg3
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| Representative Drug(s) | CC-401 | Drug Info | IC50 = 340 nM | [2] | ||
| Co-Target Name | Extracellular signal-regulated kinase 1 (ERK1) | Clinical trial Target | ||||
| UniProt ID | MK03_HUMAN | |||||
| Gene Name | MAPK3 | |||||
| Synonyms |
PRKM3; P44-MAPK; P44-ERK1; P44 Mitogen-activated protein kinase; Mitogen-activated protein kinase 3; Microtubule-associated protein-2 kinase; Microtubule-associated protein 2 kinase; MAPK 3; MAP kinase isoform p44; MAP kinase 3; Insulin-stimulated MAP2 kinase; ERT2; ERK-1
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| Representative Drug(s) | Drug Info | IC50 = 480 nM | [1] | |||
| Co-Target Name | Stress-activated protein kinase JNK3 (JNK3) | Patented-recorded Target | ||||
| UniProt ID | MK10_HUMAN | |||||
| Gene Name | MAPK10 | |||||
| Synonyms |
Stress-activated protein kinase 1b; SAPK1b; PRKM10; Mitogen-activated protein kinase 10; MAPK 10; MAP kinase p49 3F12; MAP kinase 10; JNK3A; C-Jun N-terminal kinase 3
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| Representative Drug(s) | Drug Info | IC50 = 6 nM | [3] | |||
| Co-Target Name | Stress-activated protein kinase JNK2 (JNK2) | Patented-recorded Target | ||||
| UniProt ID | MK09_HUMAN | |||||
| Gene Name | MAPK9 | |||||
| Synonyms |
Stress-activated protein kinase 1a; SAPK1a; PRKM9; Mitogen-activated protein kinase 9; Mitogen-activated protein kinase 8-interacting protein 2; MAPK 9; MAP kinase 9; Jun-N-terminal kinase 2; JNK-interacting protein 2; JNK-55; JNK MAP kinase scaffold protein 2; JIP-2; Islet-brain-2; IB-2; C-jun-amino-terminal kinase interacting protein 2; C-Jun N-terminal kinase 2
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| Representative Drug(s) | Drug Info | Ki = 6.2 nM | [1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1433-8. | ||||
| REF 2 | Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. Bioorg Med Chem. 2017 May 1;25(9):2609-16. | ||||
| REF 3 | Fibrogenic Disorders in Human Diseases: From Inflammation to Organ Dysfunction. J Med Chem. 2018 Nov 21;61(22):9811-40. | ||||
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