Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T86052 | Target Info | |||
Target Name | Telomerase reverse transcriptase (TERT) | ||||
Synonyms |
Telomerase-associated protein 2; Telomerase catalytic subunit; TRT; TP2; TCS1; HEST2; EST2
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Target Type | Clinical trial Target | ||||
Gene Name | TERT | ||||
Biochemical Class | Kinase | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
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Co-Target Name | Acetylcholinesterase (AChE) | Successful Target | ||||
UniProt ID | ACES_HUMAN | |||||
Gene Name | ACHE | |||||
Synonyms |
YT; N-ACHE; ARACHE
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Representative Drug(s) | Drug Info | IC50 = 40 nM | Click to Show More | [1] | ||
2 | Drug Info | IC50 = 100 nM | [2] | |||
Co-Target Name | Cytochrome P450 1B1 (CYP1B1) | Clinical trial Target | ||||
UniProt ID | CP1B1_HUMAN | |||||
Gene Name | CYP1B1 | |||||
Synonyms |
CYPIB1
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Representative Drug(s) | Drug Info | Ki = 44 nM | [3] |
References | Top | ||||
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REF 1 | Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6603-7. | ||||
REF 2 | Isolation of cholinesterase and beta-secretase 1 inhibiting compounds from Lycopodiella cernua. Bioorg Med Chem. 2015 Jul 1;23(13):3126-34. | ||||
REF 3 | Inhibitors of cytochrome P450 (CYP) 1B1. Eur J Med Chem. 2017 Jul 28;135:296-306. |
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