Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86836 | Target Info | |||
| Target Name | Human Deoxyribonucleic acid (hDNA) | ||||
| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Human immunodeficiency virus Reverse transcriptase (HIV RT) | Successful Target | ||||
| UniProt ID | POL_HV1B1 | |||||
| Gene Name | HIV RT | |||||
| Synonyms |
HIV p66 RT; HIV Exoribonuclease H
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| Representative Drug(s) | Daunorubicin | Drug Info | IC50 = 125 ug.mL-1 | [1] | ||
| Co-Target Name | DNA [cytosine-5]-methyltransferase 1 (DNMT1) | Clinical trial Target | ||||
| UniProt ID | DNMT1_HUMAN | |||||
| Gene Name | DNMT1 | |||||
| Synonyms |
MCMT; M.HsaI; Dnmt1; DNMT; DNA methyltransferase HsaI; DNA MTase HsaI; DNA (cytosine5)methyltransferase 1; DNA (cytosine-5)-methyltransferase 1; CXXCtype zinc finger protein 9; CXXC9; CXXC-type zinc finger protein 9; AIM
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| Representative Drug(s) | Drug Info | IC50 = 30 nM | [2] | |||
| Co-Target Name | Lysine-specific histone demethylase 1 (LSD) | Clinical trial Target | ||||
| UniProt ID | KDM1A_HUMAN | |||||
| Gene Name | KDM1A | |||||
| Synonyms |
Lysine-specific histone demethylase 1A; LSD1; KIAA0601; KDM1; Flavin-containing amine oxidase domain-containing protein 2; BRAF35-HDAC complex protein BHC110; AOF2
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| Representative Drug(s) | CGC-11047 | Drug Info | IC50 = 250 nM | [3] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora. J Nat Prod. 1997 Sep;60(9):884-8. | ||||
| REF 2 | Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy. J Med Chem. 2018 Aug 9;61(15):6518-6545. | ||||
| REF 3 | High-throughput virtual screening identifies novel N'-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors. J Med Chem. 2013 Dec 12;56(23):9496-508. | ||||
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