Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T88240 | Target Info | |||
Target Name | Bacterial Dihydropteroate synthetase (Bact folP) | ||||
Synonyms |
folP; H2Pte synthase; Dihydropteroate synthase; Dihydropteroate pyrophosphorylase; DHPS
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Target Type | Successful Target | ||||
Gene Name | Bact folP | ||||
Biochemical Class | Alkyl aryl transferase | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
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Co-Target Name | Carbonic anhydrase II (CA-II) | Successful Target | ||||
UniProt ID | CAH2_HUMAN | |||||
Gene Name | CA2 | |||||
Synonyms |
Carbonic anhydrase C; Carbonic anhydrase 2; Carbonate dehydratase II; CAC
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Representative Drug(s) | Sulfanilamide | Drug Info | Ki = 1.02 Ratio | Click to Show More | [1] | |
2 | Sulfanilamide | Drug Info | Ki = 240 nM | [3] | ||
Co-Target Name | Carbonic anhydrase XII (CA-XII) | Successful Target | ||||
UniProt ID | CAH12_HUMAN | |||||
Gene Name | CA12 | |||||
Synonyms |
Tumor antigen HOM-RCC-3.1.3; Carbonic anhydrase 12; Carbonate dehydratase XII
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Representative Drug(s) | Sulfanilamide | Drug Info | Ki = 37 nM | [2] | ||
Co-Target Name | Carbonic anhydrase I (CA-I) | Successful Target | ||||
UniProt ID | CAH1_HUMAN | |||||
Gene Name | CA1 | |||||
Synonyms |
Carbonic anhydrase B; Carbonic anhydrase 1; Carbonate dehydratase I; CAB
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Representative Drug(s) | Sulfanilamide | Drug Info | Ki = 300 nM | [4] | ||
Co-Target Name | Solute carrier family 47 member 1 (SLC47A1) | Successful Target | ||||
UniProt ID | S47A1_HUMAN | |||||
Gene Name | SLC47A1 | |||||
Synonyms |
hMATE-1; Multidrug and toxin extrusion protein 1; MATE1; MATE-1
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Representative Drug(s) | Drug Info | IC50 = 700 nM | [5] | |||
Co-Target Name | Endothelin A receptor (EDNRA) | Successful Target | ||||
UniProt ID | EDNRA_HUMAN | |||||
Gene Name | EDNRA | |||||
Synonyms |
HET-AR; Endothelin-1 receptor; Endothelin receptor type A; Endothelin receptor A; ETRA; ETA-R; ETA receptor; ETA; ET-A
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Representative Drug(s) | Sulfisoxazole | Drug Info | IC50 = 780 nM | [6] | ||
Co-Target Name | Carbonic anhydrase VI (CA-VI) | Successful Target | ||||
UniProt ID | CAH6_HUMAN | |||||
Gene Name | CA6 | |||||
Synonyms |
Secreted carbonic anhydrase; Salivary carbonic anhydrase; Carbonic anhydrase 6; Carbonate dehydratase VI
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Representative Drug(s) | Sulfanilamide | Drug Info | Ki = 941 nM | [7] | ||
Co-Target Name | Carbonic anhydrase IX (CA-IX) | Clinical trial Target | ||||
UniProt ID | CAH9_HUMAN | |||||
Gene Name | CA9 | |||||
Synonyms |
Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; PMW1; P54/58N; Membrane antigen MN; MN; G250 antigen (MN/CA IX/G250); G250; Carbonic anhydrase 9; Carbonate dehydratase IX; CAIX
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Representative Drug(s) | Sulfanilamide | Drug Info | Ki = 1.02 Ratio | Click to Show More | [1] | |
2 | Sulfanilamide | Drug Info | Ki = 238 nM | [8] | ||
Co-Target Name | Carbonic anhydrase VII (CA-VII) | Patented-recorded Target | ||||
UniProt ID | CAH7_HUMAN | |||||
Gene Name | CA7 | |||||
Synonyms |
Carbonic anhydrase 7; Carbonate dehydratase VII
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Representative Drug(s) | Sulfanilamide | Drug Info | Ki = 70 nM | [9] | ||
Co-Target Name | Organic cation transporter 3 (OCT3) | Literature-reported Target | ||||
UniProt ID | S22A3_HUMAN | |||||
Gene Name | SLC22A3 | |||||
Synonyms |
Solute carrier family 22 member 3; Extraneuronal monoamine transporter; EMTH
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Representative Drug(s) | Drug Info | IC50 = 410 nM | [5] | |||
Co-Target Name | Multidrug and toxin extrusion protein 2 (MATE2) | Literature-reported Target | ||||
UniProt ID | S47A2_HUMAN | |||||
Gene Name | SLC47A2 | |||||
Synonyms |
hMATE-2; Solute carrier family 47 member 2; MATE2; MATE-2; Kidney-specific H(+)/organic cation antiporter
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Representative Drug(s) | Drug Info | IC50 = 500 nM | [5] | |||
Co-Target Name | Carbonic anhydrase XIII (CA13) | Co-Target | ||||
UniProt ID | CAH13_HUMAN | |||||
Gene Name | CA13 | |||||
Synonyms |
Carbonic anhydrase 13; Carbonate dehydratase XIII; CA-XIII
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Representative Drug(s) | Sulfanilamide | Drug Info | Ki = 32 nM | [8] | ||
Co-Target Name | Solute carrier family 22 member 1 (SLC22A1) | Co-Target | ||||
UniProt ID | S22A1_HUMAN | |||||
Gene Name | SLC22A1 | |||||
Synonyms |
Organic cation transporter 1; hOCT1
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Representative Drug(s) | Drug Info | IC50 = 210 nM | [5] | |||
Co-Target Name | Solute carrier family 22 member 2 (SLC22A2) | Co-Target | ||||
UniProt ID | S22A2_HUMAN | |||||
Gene Name | SLC22A2 | |||||
Synonyms |
Organic cation transporter 2; hOCT2
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Representative Drug(s) | Drug Info | IC50 = 400 nM | [5] | |||
Co-Target Name | Carbonic anhydrase III (CA3) | Co-Target | ||||
UniProt ID | CAH3_HUMAN | |||||
Gene Name | CA3 | |||||
Synonyms |
Carbonic anhydrase 3; Carbonate dehydratase III; CA-III
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Representative Drug(s) | Sulfanilamide | Drug Info | Ki = 988 nM | [8] |
References | Top | ||||
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REF 1 | Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds. Bioorg Med Chem Lett. 2005 May 2;15(9):2359-64. | ||||
REF 2 | Synthesis and carbonic anhydrase I, II, IX and XII inhibition studies of 4-N,N-disubstituted sulfanilamides incorporating 4,4,4-trifluoro-3-oxo-but-1-enyl, phenacylthiourea and imidazol-2(3H)-one/thione moieties. Bioorg Med Chem Lett. 2014 Apr 1;24(7):1776-9. | ||||
REF 3 | Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. | ||||
REF 4 | Carbonic anhydrase inhibitors. Inhibition of human cytosolic isoforms I and II with (reduced) Schiff's bases incorporating sulfonamide, carboxylate and carboxymethyl moieties. Bioorg Med Chem. 2014 May 15;22(10):2867-74. | ||||
REF 5 | Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem. 2013 Feb 14;56(3):781-795. | ||||
REF 6 | Selective optimization of side activities: another way for drug discovery. J Med Chem. 2004 Mar 11;47(6):1303-14. | ||||
REF 7 | Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies. Bioorg Med Chem. 2014 Jan 1;22(1):334-40. | ||||
REF 8 | The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors. J Med Chem. 2010 Jan 28;53(2):850-4. | ||||
REF 9 | Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):971-6. |
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