Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T88304 Target Info
Target Name DNA [cytosine-5]-methyltransferase 1 (DNMT1)
Synonyms
MCMT; M.HsaI; Dnmt1; DNMT; DNA methyltransferase HsaI; DNA MTase HsaI; DNA (cytosine5)methyltransferase 1; DNA (cytosine-5)-methyltransferase 1; CXXCtype zinc finger protein 9; CXXC9; CXXC-type zinc finger protein 9; AIM
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Target Type Clinical trial Target
Gene Name DNMT1
Biochemical Class Methyltransferase
UniProt ID
DNMT1_HUMAN
Co-Targets of This Target  Top
Co-Target Name Poly [ADP-ribose] polymerase 1 (PARP1) Successful Target
UniProt ID PARP1_HUMAN
Gene Name PARP1
Synonyms
Protein poly-ADP-ribosyltransferase PARP1; Poly[ADP-ribose] synthetase-1; Poly[ADP-ribose] synthase 1; Poly(ADP-ribose)polymerase-1; PPOL; PARP-1; NAD(+)Poly [ADP-ribose] polymerase-1 ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase 1; DNA ADP-ribosyltransferase PARP1; ARTD1; ADPRT 1; ADPRT; ADP-ribosyltransferase diphtheria toxin-like 1
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Representative Drug(s) CC-486 Drug Info Ki = 5.8 nM [1]
References  Top
REF 1 Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors. J Med Chem. 2003 Jan 16;46(2):210-3.

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