Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T89515 | Target Info | |||
Target Name | Polypeptide deformylase (PDF) | ||||
Synonyms |
PDF
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Target Type | Successful Target | ||||
Gene Name | |||||
Biochemical Class | CH-NH donor oxidoreductase | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
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Co-Target Name | Solute carrier family 19 member 1 (SLC19A1) | Successful Target | ||||
UniProt ID | S19A1_HUMAN | |||||
Gene Name | SLC19A1 | |||||
Synonyms |
Reduced folate carrier protein; RFC1; RFC; Placental folate transporter; Intestinal folate carrier 1; IFC-1; Folate transporter 1; FOLT; FLOT1
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Representative Drug(s) | Pralatrexate | Drug Info | IC50 = 0.69 nM | [1] | ||
Co-Target Name | Dihydrofolate reductase (DHFR) | Successful Target | ||||
UniProt ID | DYR_HUMAN | |||||
Gene Name | DHFR | |||||
Synonyms |
DYR; DHFRP1
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Representative Drug(s) | Drug Info | IC50 < 1 nM | [2] | |||
Co-Target Name | Proton-coupled folate transporter (SLC46A1) | Successful Target | ||||
UniProt ID | PCFT_HUMAN | |||||
Gene Name | SLC46A1 | |||||
Synonyms |
Solute carrier family 46 member 1; PCFT/HCP1; PCFT; Heme carrier protein 1; HCP1; G21
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Representative Drug(s) | Pralatrexate | Drug Info | IC50 = 57 nM | [1] | ||
Co-Target Name | Folate receptor alpha (FOLR1) | Successful Target | ||||
UniProt ID | FOLR1_HUMAN | |||||
Gene Name | FOLR1 | |||||
Synonyms |
Ovarian tumorassociated antigen MOv18; KB cells FBP; Folate receptor, adult; Folate receptor 1; FRalpha; FOLR1; Adult folatebinding protein
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Representative Drug(s) | Pralatrexate | Drug Info | IC50 = 168 nM | [1] | ||
Co-Target Name | Protein kinase C gamma (PRKCG) | Successful Target | ||||
UniProt ID | KPCG_HUMAN | |||||
Gene Name | PRKCG | |||||
Synonyms |
PRKCG; PKCG; PKC-gamma
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Representative Drug(s) | Drug Info | IC50 = 300 nM | Click to Show More | [3] | ||
2 | Drug Info | IC50 = 300 nM | [4] | |||
Co-Target Name | Protein kinase C alpha (PRKCA) | Successful Target | ||||
UniProt ID | KPCA_HUMAN | |||||
Gene Name | PRKCA | |||||
Synonyms |
Protein kinase C alpha type; PRKACA; PKCalpha; PKCA; PKC-alpha; PKC-A
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Representative Drug(s) | Drug Info | IC50 = 360 nM | Click to Show More | [3] | ||
2 | Drug Info | IC50 = 360 nM | [5] | |||
Co-Target Name | Protein kinase C epsilon (PRKCE) | Successful Target | ||||
UniProt ID | KPCE_HUMAN | |||||
Gene Name | PRKCE | |||||
Synonyms |
Protein kinase C epsilon type; PKCE; PKC epsilon; NPKC-epsilon
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Representative Drug(s) | Drug Info | IC50 = 600 nM | Click to Show More | [6] | ||
2 | Drug Info | IC50 = 600 nM | [3] | |||
Co-Target Name | Protein kinase C beta (PRKCB) | Clinical trial Target | ||||
UniProt ID | KPCB_HUMAN | |||||
Gene Name | PRKCB | |||||
Synonyms |
Protein kinase C beta type; PRKCB1; PKCB; PKC-beta; PKC-B
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Representative Drug(s) | Drug Info | IC50 = 4.7 nM | Click to Show More | [3] | ||
2 | Drug Info | IC50 = 4.7 nM | [4] | |||
Co-Target Name | Serine/threonine-protein kinase pim-1 (PIM1) | Clinical trial Target | ||||
UniProt ID | PIM1_HUMAN | |||||
Gene Name | PIM1 | |||||
Synonyms |
Pim-1 proto-oncogene, serine/threonine kinase; PIM
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Representative Drug(s) | Drug Info | IC50 = 200 nM | [7] | |||
Co-Target Name | Protein kinase C delta (PRKCD) | Clinical trial Target | ||||
UniProt ID | KPCD_HUMAN | |||||
Gene Name | PRKCD | |||||
Synonyms |
nPKC-delta; Tyrosine-protein kinase PRKCD; SDK1; Protein kinase C delta type catalytic subunit; Protein kinase C delta type; PKC-delta
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Representative Drug(s) | Drug Info | IC50 = 250 nM | Click to Show More | [6] | ||
2 | Drug Info | IC50 = 250 nM | [3] | |||
Co-Target Name | Phosphoinositide dependent protein kinase-1 (PDPK1) | Clinical trial Target | ||||
UniProt ID | PDPK1_HUMAN | |||||
Gene Name | PDPK1 | |||||
Synonyms |
PDK1; HPDK1; 3-phosphoinositide-dependent protein kinase 1; 3-Phosphoinositide-dependent kinase-1; 3'-phosphoinositide dependent kinase 1
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Representative Drug(s) | Drug Info | IC50 = 750 nM | [4] | |||
Co-Target Name | Protein kinase C eta (PRKCH) | Co-Target | ||||
UniProt ID | KPCL_HUMAN | |||||
Gene Name | PRKCH | |||||
Synonyms |
Protein kinase C eta type; PKC-L; nPKC-eta
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Representative Drug(s) | Drug Info | IC50 = 52 nM | Click to Show More | [6] | ||
2 | Drug Info | IC50 = 52 nM | [3] |
References | Top | ||||
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REF 1 | Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3- d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis. J Med Chem. 2018 Mar 8;61(5):2027-40. | ||||
REF 2 | Selective inhibitors of Candida albicans dihydrofolate reductase: activity and selectivity of 5-(arylthio)-2,4-diaminoquinazolines. J Med Chem. 1995 Sep 1;38(18):3608-16. | ||||
REF 3 | Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCbeta. Bioorg Med Chem Lett. 2003 Jun 2;13(11):1857-9. | ||||
REF 4 | Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition. Bioorg Med Chem. 2018 Aug 7;26(14):4209-24. | ||||
REF 5 | Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors. J Med Chem. 2003 Sep 11;46(19):4021-31. | ||||
REF 6 | (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71. | ||||
REF 7 | A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. |
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