Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T93515 | Target Info | |||
| Target Name | P2Y purinoceptor 2 (P2RY2) | ||||
| Synonyms |
P2Y2; P2U1; P2U receptor; P2U purinoceptor 1; P2U nucleotide receptor; P2RY2; Adenosine P2Y2 receptor
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| Target Type | Clinical trial Target | ||||
| Gene Name | P2RY2 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | P2Y purinoceptor 6 (P2RY6) | Clinical trial Target | ||||
| UniProt ID | P2RY6_HUMAN | |||||
| Gene Name | P2RY6 | |||||
| Synonyms |
P2Y6; P2RY6; Adenosine P2Y6 receptor
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| Representative Drug(s) | INS-37217 | Drug Info | EC50 ~ 1000 nM | [1] | ||
| Co-Target Name | P2Y purinoceptor 4 (P2RY4) | Discontinued Target | ||||
| UniProt ID | P2RY4_HUMAN | |||||
| Gene Name | P2RY4 | |||||
| Synonyms |
Uridine nucleotide receptor; UNR; P2Y4; P2P; NRU
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| Representative Drug(s) | Diquafosol | Drug Info | EC50 = 130 nM | Click to Show More | [2] | |
| 2 | INS-37217 | Drug Info | EC50 = 800 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2011 Apr 28;54(8):2878-90. | ||||
| REF 2 | Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate. J Med Chem. 2007 Mar 22;50(6):1166-76. | ||||
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