Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T96788 | Target Info | |||
Target Name | ERBB2 messenger RNA (HER2 mRNA) | ||||
Synonyms |
Tyrosine kinase-type cell surface receptor HER2 (mRNA); Tyrosine kinase receptor ErbB2 (mRNA); Receptor tyrosine-protein kinase erbB-2 (mRNA); Proto-oncogene c-ErbB-2 (mRNA); Proto-oncogene Neu (mRNA); P185erbB2 (mRNA); NGL (mRNA); NEU proto-oncogene (mRNA); NEU (mRNA); Metastatic lymph node gene 19 protein (mRNA); MLN19 (mRNA); MLN 19 (mRNA); HER2/neu (mRNA); HER2 (erbB2/neu) (mRNA); HER-2 (mRNA); Erb2 (mRNA); Epidermal growth factor receptor 2 (mRNA); CD340 (mRNA); C-erbB-2 oncoprotein (mRNA); C-erbB-2 (mRNA)
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Target Type | Clinical trial Target | ||||
Gene Name | ERBB2 | ||||
Biochemical Class | mRNA target | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
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Co-Target Name | Epidermal growth factor receptor (EGFR) | Successful Target | ||||
UniProt ID | EGFR_HUMAN | |||||
Gene Name | EGFR | |||||
Synonyms |
Receptor tyrosine-protein kinase erbB-1; Proto-oncogene c-ErbB-1; HER1; ERBB1; ERBB
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Representative Drug(s) | HKI-272 | Drug Info | IC50 = 0.08 nM | [1] | ||
Co-Target Name | Erbb2 tyrosine kinase receptor (HER2) | Successful Target | ||||
UniProt ID | ERBB2_HUMAN | |||||
Gene Name | ERBB2 | |||||
Synonyms |
p185erbB2; Tyrosine kinase-type cell surface receptor HER2; Receptor tyrosine-protein kinase erbB-2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; NGL; NEU; Metastatic lymph node gene 19 protein; MLN19; MLN 19; HER2; CD340
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Representative Drug(s) | HKI-272 | Drug Info | IC50 = 3 nM | [2] | ||
Co-Target Name | Erbb4 tyrosine kinase receptor (Erbb-4) | Successful Target | ||||
UniProt ID | ERBB4_HUMAN | |||||
Gene Name | ERBB4 | |||||
Synonyms |
Tyrosine kinase-type cell surface receptor HER4; Receptor tyrosine-protein kinase erbB-4; Proto-oncogene-like protein c-ErbB-4; P180erbB4; HER4
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Representative Drug(s) | HKI-272 | Drug Info | IC50 = 3 nM | [2] | ||
Co-Target Name | Vascular endothelial growth factor receptor 2 (KDR) | Successful Target | ||||
UniProt ID | VGFR2_HUMAN | |||||
Gene Name | KDR | |||||
Synonyms |
VEGFR2; VEGFR-2; VEGF-2 receptor; Protein-tyrosine kinase receptor flk-1; Kinase insert domain receptor; Fetal liver kinase 1; FLK1; FLK-1; CD309
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Representative Drug(s) | HKI-272 | Drug Info | IC50 = 858.2 nM | [1] | ||
Co-Target Name | Erbb3 tyrosine kinase receptor (Erbb-3) | Clinical trial Target | ||||
UniProt ID | ERBB3_HUMAN | |||||
Gene Name | ERBB3 | |||||
Synonyms |
Tyrosine kinase-type cell surface receptor HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; HER3; C-erbB3; C-erbB-3 protein
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Representative Drug(s) | HKI-272 | Drug Info | IC50 = 3 nM | [2] | ||
Co-Target Name | NIMA-related kinase 2 (NEK2) | Literature-reported Target | ||||
UniProt ID | NEK2_HUMAN | |||||
Gene Name | NEK2 | |||||
Synonyms |
Serine/threonine-protein kinase Nek2; NimA-related protein kinase 2; NimA-like protein kinase 1; Never in mitosis A-related kinase 2; NLK1; NEK2A; HSPK 21
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Representative Drug(s) | HKI-272 | Drug Info | IC50 = 274 nM | [3] |
References | Top | ||||
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REF 1 | Dual irreversible kinase inhibitors: quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cyst... Bioorg Med Chem. 2007 Jun 1;15(11):3635-48. | ||||
REF 2 | Discovery of novel selective inhibitors for EGFR-T790M/L858R. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1365-70. | ||||
REF 3 | Therapeutic melting pot of never in mitosis gene a related kinase 2 (Nek2): a perspective on Nek2 as an oncology target and recent advancements in Nek2 small molecule inhibition. J Med Chem. 2014 Jul 24;57(14):5835-44. |
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