Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T98269 | Target Info | |||
Target Name | Caspase-1 (CASP1) | ||||
Synonyms |
P45; Interleukin-1 beta-converting enzyme; Interleukin-1 beta converting enzyme; Interleukin-1 beta convertase; IL1BCE; IL1BC; IL-1BC; IL-1 beta-converting enzyme; IL-1 beta converting enzyme; ICE; CASP-1
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Target Type | Clinical trial Target | ||||
Gene Name | CASP1 | ||||
Biochemical Class | Peptidase | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
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Co-Target Name | Caspase-8 (CASP8) | Patented-recorded Target | ||||
UniProt ID | CASP8_HUMAN | |||||
Gene Name | CASP8 | |||||
Synonyms |
MORT1-associated CED-3 homolog; MCH5; MACH; ICE-like apoptotic protease 5; FLICE; FADD-like ICE; FADD-homologous ICE/CED-3-like protease; CASP-8; CAP4; Apoptotic protease Mch-5; Apoptotic cysteine protease
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Representative Drug(s) | Drug Info | IC50 = 40 nM | [1] |
References | Top | ||||
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REF 1 | Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1beta converting enzyme (ICE) inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4233-6. |
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