Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T99347 Target Info
Target Name Metabotropic glutamate receptor 5 (mGluR5)
Synonyms
MGLUR5; GPRC1E
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Target Type Clinical trial Target
Gene Name GRM5
Biochemical Class GPCR glutamate
UniProt ID
GRM5_HUMAN
Co-Targets of This Target  Top
Co-Target Name Amyloid beta A4 protein (APP) Successful Target
UniProt ID A4_HUMAN
Gene Name APP
Synonyms
Protease nexin-II; PreA4; PN-II; Cerebral vascular amyloid peptide; CVAP; Amyloid-beta precursor protein; Amyloid-beta A4 protein; Alzheimer disease amyloid protein; APPI; APP; AD1; ABPP; A4
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Representative Drug(s) MK-3328 Drug Info IC50 = 10.5 nM [1]
References  Top
REF 1 Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as beta-Amyloid PET Ligands and Identification of MK-3328. ACS Med Chem Lett. 2011 Apr 18;2(7):498-502.

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