Resistance mutation info of drug
| Drug General Information | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug ID | D07UHS | ||||||||||
| Drug Name | Fingolimod | ||||||||||
| Synonyms | 2-Amino-2-(4-octylphenethyl)propane-1,3-diol | ||||||||||
| Drug Type | Small molecular drug | ||||||||||
| Company | Novartis | ||||||||||
| Structure |
|
||||||||||
| Drug Resistance Mutations | |||||||||||
| Target Name | Sphingosine 1-phosphate receptor 1 (S1PR1) | Target Info | |||||||||
| Gene Name | S1PR1 | ||||||||||
| Uniprot ID | S1PR1_HUMAN | ||||||||||
| Species | Homo sapiens | ||||||||||
| Reference Sequence |
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH PQKDEGDNPETIMSSGNVNSSS [Homo sapiens] |
||||||||||
| Targeted Disease | Multiple sclerosis | ||||||||||
| Drug Resistance Mutations |
|
||||||||||
|
|||||||||||
| References | |||||||||||
| REF 1 | Individual variation of human S1P coding sequence leads to heterogeneity in receptor function and drug interactions.J Lipid Res.2014 Dec;55(12):2665-75. | ||||||||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.