| Drug General Information |
| Drug ID |
D08QME
|
| Drug Name |
Ethambutol |
|
| Synonyms |
Aethambutolum; Diambutol; EMB; Etambutol; Etambutolo; Ethambutolum; Etibi; Miambutol; Myambutol; Purderal; Servambutol; Tibutol; Etambutolo [DCIT]; CL 40881 (dihydrochloride); D-Ethambutol; Etambutol [INN-Spanish]; Ethambutol & EEP; Ethambutol & Propolis; Ethambutol (INN); Ethambutol [INN:BAN]; Ethambutol, meso form; Ethambutol, racemic mixture; Ethambutolum [INN-Latin]; Myambutol (TN); Myambutol (dihydrochloride); Servambutol (TN); Ethambutol, (-)-isomer; D,N,N'-Bis(1-hydroxymethylpropyl)ethylenediamine; D-N,N'-Bis(1-hydroxymethylpropyl)ethylenediamine; D-2,2'-(Ethylenediimino)bis(1-butanol); D-2,2'-(Ethylenediimino)di-1-butanol; (+)-(S,S)-2,2'-(1,2-Ethylenediimino)-di-1-butanol; (+)-2,2'-(Ethylenediimino)di-1-butanol; (+)-N,N'-Bis(1-(hydroxymethyl)propyl)ethylenediamine; (+)-S,S-Ethambutol; (+)-ethambutol; (-)-(R,R)-2,2'-(1,2-Ethylenediimino)-di-1-butanol; (2'S)-2,2'-[Ethane-1,2-diyldi(imino)]dibutan-1-ol; (2R)-2-[2-(1-hydroxybutan-2-ylamino)ethylamino]butan-1-ol; (2R)-2-[2-[[(2R)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol; (2S)-2-[2-(1-hydroxybutan-2-ylamino)ethylamino]butan-1-ol; (2S)-2-[2-[[(2R)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol; (2S,2'S)-2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol; (2S,7S)-2,7-diethyl-3,6-diazaoctane-1,8-diol; (R)-2,2'-(1,2-Ethanediyldiimino)bis-1-butanol; (S,R)-2,2'-(1,2-Ethylenediimino)-di-1-butanol; (S,S)-ethambutol; 2,2'-(1,2-Ethylenediimino)-di-1-butanol; 2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol; 2-[2-(1-hydroxybutan-2-ylamino)ethylamino]butan-1-ol |
| Drug Type |
Small molecular drug |
| Therapeutic Class |
Antitubercular Agents |
| Company |
Macleods Pharmaceutical. Ltd |
| Structure |
|
| Drug Resistance Mutations |
| Target Name |
Bacterial Probable arabinosyltransferase C (embB) |
Target Info |
| Gene Name |
embB |
| Uniprot ID |
EMBB_MYCTU |
| Species |
Mycobacterium tuberculosis |
| Reference Sequence |
MTQCASRRKSTPNRAILGAFASARGTRWVATIAGLIGFVLSVATPLLPVVQTTAMLDWPQ
RGQLGSVTAPLISLTPVDFTATVPCDVVRAMPPAGGVVLGTAPKQGKDANLQALFVVVSA
QRVDVTDRNVVILSVPREQVTSPQCQRIEVTSTHAGTFANFVGLKDPSGAPLRSGFPDPN
LRPQIVGVFTDLTGPAPPGLAVSATIDTRFSTRPTTLKLLAIIGAIVATVVALIALWRLD
QLDGRGSIAQLLLRPFRPASSPGGMRRLIPASWRTFTLTDAVVIFGFLLWHVIGANSSDD
GYILGMARVADHAGYMSNYFRWFGSPEDPFGWYYNLLALMTHVSDASLWMRLPDLAAGLV
CWLLLSREVLPRLGPAVEASKPAYWAAAMVLLTAWMPFNNGLRPEGIIALGSLVTYVLIE
RSMRYSRLTPAALAVVTAAFTLGVQPTGLIAVAALVAGGRPMLRILVRRHRLVGTLPLVS
PMLAAGTVILTVVFADQTLSTVLEATRVRAKIGPSQAWYTENLRYYYLILPTVDGSLSRR
FGFLITALCLFTAVFIMLRRKRIPSVARGPAWRLMGVIFGTMFFLMFTPTKWVHHFGLFA
AVGAAMAALTTVLVSPSVLRWSRNRMAFLAALFFLLALCWATTNGWWYVSSYGVPFNSAM
PKIDGITVSTIFFALFAIAAGYAAWLHFAPRGAGEGRLIRALTTAPVPIVAGFMAAVFVA
SMVAGIVRQYPTYSNGWSNVRAFVGGCGLADDVLVEPDTNAGFMKPLDGDSGSWGPLGPL
GGVNPVGFTPNGVPEHTVAEAIVMKPNQPGTDYDWDAPTKLTSPGINGSTVPLPYGLDPA
RVPLAGTYTTGAQQQSTLVSAWYLLPKPDDGHPLVVVTAAGKIAGNSVLHGYTPGQTVVL
EYAMPGPGALVPAGRMVPDDLYGEQPKAWRNLRFARAKMPADAVAVRVVAEDLSLTPEDW
IAVTPPRVPDLRSLQEYVGSTQPVLLDWAVGLAFPCQQPMLHANGIAEIPKFRITPDYSA
KKLDTDTWEDGTNGGLLGITDLLLRAHVMATYLSRDWARDWGSLRKFDTLVDAPPAQLEL
GTATRSGLWSPGKIRIGP [Mycobacterium tuberculosis]
|
| Targeted Disease |
Tuberculosis |
| Drug Resistance Mutations |
| Mutation info |
Missense: G406A |
[1], [2], [3] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: G406D |
[1], [3], [4] |
| Mutation Frequency |
2 out of 44 isolates |
|
| Mutation info |
Missense: M306L |
[3], [5], [6] |
| Mutation Frequency |
8 out of 19 isolates |
|
| Mutation info |
Missense: D1024N |
[1], [3] |
|
| Mutation info |
Missense: D328G |
[1], [3] |
|
| Mutation info |
Missense: D328Y |
[1], [3] |
|
| Mutation info |
Missense: D959A |
[1], [3] |
|
| Mutation info |
Missense: G406C |
[1], [3] |
|
| Mutation info |
Missense: G406S |
[1], [3] |
|
| Mutation info |
Missense: G745D |
[1], [3] |
|
| Mutation info |
Missense: M1000R |
[1], [3] |
|
| Mutation info |
Missense: Q497K |
[1], [3] |
|
| Mutation info |
Missense: Q497R |
[1], [3] |
|
| Mutation info |
Missense: S297A |
[1], [3] |
|
| Mutation info |
Missense: Y334H |
[1], [3] |
|
| Mutation info |
Missense: M306T |
[5], [3] |
|
| Mutation info |
Missense: Y319C |
[9], [3] |
|
| Mutation info |
Missense: Y319N |
[10], [3] |
|
| Mutation info |
Missense: F330V |
[6], [3] |
|
| Mutation info |
Missense: A356V |
[4], [3] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: A357S |
[4], [3] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: D240H |
[2], [3] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: D299E |
[2], [3] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: D311H |
[2], [3] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: E368A |
[2], [3] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: E378A |
[2], [3] |
| Mutation Frequency |
2 out of 16 isolates |
|
| Mutation info |
Missense: I465D |
[2], [3] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: L239P |
[2], [3] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: M306I |
[6], [3] |
| Mutation Frequency |
8 out of 19 isolates |
|
| Mutation info |
Missense: M306V |
[6], [3] |
| Mutation Frequency |
8 out of 19 isolates |
|
| Mutation info |
Missense: N399H |
[4], [3] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: P375A |
[4], [3] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: P397Q |
[2], [3] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: P446H |
[2], [3] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: R460C |
[4], [3] |
| Mutation Frequency |
4 out of 44 isolates |
|
| Mutation info |
Missense: R469P |
[2], [3] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: R471P |
[2], [3] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: S380R |
[2], [3] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Frameshift: Plus 328 |
[11] |
|
| Mutation info |
Missense: S347T |
[11] |
|
| Mutation info |
Missense: D331Y |
[5] |
|
| Mutation info |
Missense: G314A |
[5] |
|
| Mutation info |
Missense: Y322C |
[5] |
|
| Mutation info |
Missense: R274P |
[12] |
|
| Mutation info |
Missense: A659T |
[13] |
| Mutation Frequency |
4 out of 20 isolates |
|
| Mutation info |
Missense: M423I |
[13] |
| Mutation Frequency |
4 out of 20 isolates |
|
| Mutation info |
Missense: G314E |
[14] |
|
| Mutation info |
Missense: Y333H |
[9] |
|
| Mutation info |
Missense: D328V |
[15] |
|
| Mutation info |
Missense: S297L |
[15] |
|
| Mutation info |
Missense: W332L |
[15] |
|
| Mutation info |
Missense: Y319S |
[15] |
|
| Mutation info |
Missense: A221G |
[2] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: A225S |
[2] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: A271V |
[2] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: A281P |
[2] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: F281L |
[2] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: F287C |
[2] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: F287V |
[2] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: G294S |
[2] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: I293N |
[2] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: S272C |
[2] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: S272I |
[2] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: V128G |
[2] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: V227G |
[2] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: V282L |
[2] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: A310R |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: A356F |
[4] |
| Mutation Frequency |
2 out of 44 isolates |
|
| Mutation info |
Missense: A356S |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: A357V |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: A379D |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: A379T |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: A388G |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: A431T |
[4] |
| Mutation Frequency |
2 out of 44 isolates |
|
| Mutation info |
Missense: D311R |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: E368D |
[4] |
| Mutation Frequency |
2 out of 44 isolates |
|
| Mutation info |
Missense: E368Q |
[4] |
| Mutation Frequency |
3 out of 44 isolates |
|
| Mutation info |
Missense: E378K |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: E405P |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: F398H |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: F398Y |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: G331R |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: G358V |
[4] |
| Mutation Frequency |
3 out of 44 isolates |
|
| Mutation info |
Missense: G374V |
[4] |
| Mutation Frequency |
2 out of 44 isolates |
|
| Mutation info |
Missense: G401S |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: G406P |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: G448V |
[4] |
| Mutation Frequency |
3 out of 44 isolates |
|
| Mutation info |
Missense: G459A |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: H312R |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: L359I |
[4] |
| Mutation Frequency |
2 out of 44 isolates |
|
| Mutation info |
Missense: L370R |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: N296K |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: N318H |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: N318K |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: N318S |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: N399D |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: N400K |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: N400P |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: P371R |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: P397T |
[4] |
| Mutation Frequency |
3 out of 44 isolates |
|
| Mutation info |
Missense: P430L |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: P461S |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: R257W |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: R367P |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: R434G |
[4] |
|
| Mutation info |
Missense: R460L |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: S317T |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: S347I |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: S366P |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: S380D |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: T437A |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: V282G |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: V309G |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: V360M |
[4] |
| Mutation Frequency |
3 out of 44 isolates |
|
| Mutation info |
Missense: V369A |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: V369L |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: V377G |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: V377M |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: V435G |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: V436G |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: V452L |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: W395C |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: W395R |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: Y315L |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: Y384N |
[4] |
| Mutation Frequency |
2 out of 44 isolates |
|
| Mutation info |
Missense: F285L |
[6] |
|
| Mutation info |
Missense: T630I |
[6] |
|
| Mutation info |
Missense: E504Q |
[3] |
|
| Mutation info |
Missense: L413P |
[3] |
|
| Mutation info |
Missense: R507G |
[3] |
|
| Mutation info |
Missense: Y333C |
[3] |
|
| Mutation info |
Missense: F1012S |
[7] |
|
| Mutation info |
Missense: Q998R |
[7] |
|
| Mutation info |
Missense: T610K |
[7] |
|
| Target Name |
Bacterial Probable arabinosyltransferase C (embC) |
Target Info |
| Gene Name |
embC |
| Uniprot ID |
EMBC_MYCTU |
| Species |
Mycobacterium tuberculosis |
| Reference Sequence |
MATEAAPPRIAVRLPSTSVRDAGANYRIARYVAVVAGLLGAVLAIATPLLPVNQTTAQLN
WPQNGTFASVEAPLIGYVATDLNITVPCQAAAGLAGSQNTGKTVLLSTVPKQAPKAVDRG
LLLQRANDDLVLVVRNVPLVTAPLSQVLGPTCQRLTFTAHADRVAAEFVGLVQGPNAEHP
GAPLRGERSGYDFRPQIVGVFTDLAGPAPPGLSFSASVDTRYSSSPTPLKMAAMILGVAL
TGAALVALHILDTADGMRHRRFLPARWWSTGGLDTLVIAVLVWWHFVGANTSDDGYILTM
ARVSEHAGYMANYYRWFGTPEAPFGWYYDLLALWAHVSTASIWMRLPTLAMALTCWWVIS
REVIPRLGHAVKTSRAAAWTAAGMFLAVWLPLDNGLRPEPIIALGILLTWCSVERAVATS
RLLPVAIACIIGALTLFSGPTGIASIGALLVAIGPLRTILHRRSRRFGVLPLVAPILAAA
TVTAIPIFRDQTFAGEIQANLLKRAVGPSLKWFDEHIRYERLFMASPDGSIARRFAVLAL
VLALAVSVAMSLRKGRIPGTAAGPSRRIIGITIISFLAMMFTPTKWTHHFGVFAGLAGSL
GALAAVAVTGAAMRSRRNRTVFAAVVVFVLALSFASVNGWWYVSNFGVPWSNSFPKWRWS
LTTALLELTVLVLLLAAWFHFVANGDGRRTARPTRFRARLAGIVQSPLAIATWLLVLFEV
VSLTQAMISQYPAWSVGRSNLQALAGKTCGLAEDVLVELDPNAGMLAPVTAPLADALGAG
LSEAFTPNGIPADVTADPVMERPGDRSFLNDDGLITGSEPGTEGGTTAAPGINGSRARLP
YNLDPARTPVLGSWRAGVQVPAMLRSGWYRLPTNEQRDRAPLLVVTAAGRFDSREVRLQW
ATDEQAAAGHHGGSMEFADVGAAPAWRNLRAPLSAIPSTATQVRLVADDQDLAPQHWIAL
TPPRIPRVRTLQNVVGAADPVFLDWLVGLAFPCQRPFGHQYGVDETPKWRILPDRFGAEA
NSPVMDHNGGGPLGITELLMRATTVASYLKDDWFRDWGALQRLTPYYPDAQPADLNLGTV
TRSGLWSPAPLRRG [Mycobacterium tuberculosis]
|
| Targeted Disease |
Tuberculosis |
| Drug Resistance Mutations |
| Mutation info |
Missense: T270I |
[3], [4], [6] |
| Mutation Frequency |
14 out of 44 isolates |
|
| Mutation info |
Missense: N394D |
[1], [3] |
|
| Mutation info |
Missense: R738Q |
[1], [3] |
|
| Mutation info |
Missense: V981L |
[6], [3] |
|
| Mutation info |
Missense: A247P |
[4], [3] |
| Mutation Frequency |
2 out of 44 isolates |
|
| Mutation info |
Missense: A254G |
[2], [3] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: A307T |
[4], [3] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: G288V |
[4], [3] |
| Mutation Frequency |
4 out of 44 isolates |
|
| Mutation info |
Missense: G288W |
[4], [3] |
| Mutation Frequency |
6 out of 44 isolates |
|
| Mutation info |
Missense: G308D |
[4], [3] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: G325S |
[4], [3] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: H285Y |
[4], [3] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: I297L |
[4], [3] |
| Mutation Frequency |
3 out of 44 isolates |
|
| Mutation info |
Missense: I297T |
[4], [3] |
| Mutation Frequency |
8 out of 44 isolates |
|
| Mutation info |
Missense: L251R |
[2], [3] |
| Mutation Frequency |
16 out of 23 isolates in all embB mutations |
|
| Mutation info |
Missense: M300R |
[4], [3] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: M310K |
[4], [3] |
| Mutation Frequency |
4 out of 44 isolates |
|
| Mutation info |
Missense: R302G |
[4], [3] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: V287F |
[4], [3] |
| Mutation Frequency |
2 out of 44 isolates |
|
| Mutation info |
Missense: V303G |
[4], [3] |
| Mutation Frequency |
6 out of 44 isolates |
|
| Mutation info |
Missense: W326R |
[4], [3] |
| Mutation Frequency |
3 out of 44 isolates |
|
| Mutation info |
Missense: Y296H |
[4], [3] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: Y296S |
[4], [3] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: Y309N |
[4], [3] |
| Mutation Frequency |
2 out of 44 isolates |
|
| Mutation info |
Missense: Y327N |
[4], [3] |
| Mutation Frequency |
4 out of 44 isolates |
|
| Mutation info |
Missense: A244T |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: G272S |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: G5S |
[6] |
|
| Mutation info |
Missense: L502P |
[3] |
|
| Mutation info |
Missense: P398S |
[3] |
|
| Mutation info |
Missense: Q491R |
[3] |
|
| Target Name |
Bacterial Isoniazid-induced protein (IniA) |
Target Info |
| Gene Name |
inia |
| Uniprot ID |
INIA_MYCTU |
| Species |
Mycobacterium tuberculosis |
| Reference Sequence |
MVPAGLCAYRDLRRKRARKWGDTVTQPDDPRRVGVIVELIDHTIAIAKLNERGDLVQRLT
RARQRITDPQVRVVIAGLLKQGKSQLLNSLLNLPAARVGDDEATVVITVVSYSAQPSARL
VLAAGPDGTTAAVDIPVDDISTDVRRAPHAGGREVLRVEVGAPSPLLRGGLAFIDTPGVG
GLGQPHLSATLGLLPEADAVLVVSDTSQEFTEPEMWFVRQAHQICPVGAVVATKTDLYPR
WREIVNANAAHLQRARVPMPIIAVSSLLRSHAVTLNDKELNEESNFPAIVKFLSEQVLSR
ATERVRAGVLGEIRSATEQLAVSLGSELSVVNDPNLRDRLASDLERRKREAQQAVQQTAL
WQQVLGDGFNDLTADVDHDLRTRFRTVTEDAERQIDSCDPTAHWAEIGNDVENAIATAVG
DNFVWAYQRSEALADDVARSFADAGLDSVLSAELSPHVMGTDFGRLKALGRMESKPLRRG
HKMIIGMRGSYGGVVMIGMLSSVVGLGLFNPLSVGAGLILGRMAYKEDKQNRLLRVRSEA
KANVRRFVDDISFVVSKQSRDRLKMIQRLLRDHYREIAEEITRSLTESLQATIAAAQVAE
TERDNRIRELQRQLGILSQVNDNLAGLEPTLTPRASLGRA [Mycobacterium tube
rculosis]
|
| Targeted Disease |
Tuberculosis |
| Drug Resistance Mutations |
| Mutation info |
Missense: G308R |
[1], [7] |
|
| Mutation info |
Missense: S501W |
[1], [7] |
|
| Mutation info |
Missense: P3A |
[7] |
|
| Mutation info |
Missense: R537H |
[7] |
|
| Target Name |
Bacterial Isoniazid-induced protein (IniC) |
Target Info |
| Gene Name |
iniC |
| Uniprot ID |
INIC_MYCTU |
| Species |
Mycobacterium tuberculosis |
| Reference Sequence |
MSTSDRVRAILHATIQAYRGAPAYRQRGDVFCQLDRIGARLAEPLRIALAGTLKAGKSTL
VNALVGDDIAPTDATEATRIVTWFRHGPTPRVTANHRGGRRANVPITRRGGLSFDLRRIN
PAELIDLEVEWPAEELIDATIVDTPGTSSLACDASERTLRLLVPADGVPRVDAVVFLLRT
LNAADVALLKQIGGLVGGSVGALGIIGVASRADEIGAGRIDAMLSANDVAKRFTRELNQM
GICQAVVPVSGLLALTARTLRQTEFIALRKLAGAERTELNRALLSVDRFVRRDSPLPVDA
GIRAQLLERFGMFGIRMSIAVLAAGVTDSTGLAAELLERSGLVALRNVIDQQFAQRSDML
KAHTALVSLRRFVQTHPVPATPYVIADIDPLLADTHAFEELRMLSLLPSRATTLNDDEIA
SLRRIIGGSGTSAAARLGLDPANSREAPRAALAAAQHWRRRAAHPLNDPFTTRACRAAVR
SAEAMVAEFSARR [Mycobacterium tuberculosis]
|
| Targeted Disease |
Tuberculosis |
| Drug Resistance Mutations |
| Mutation info |
Missense: P248A |
[1], [7] |
|
| Mutation info |
Nonsense: Q351 STOP |
[1] |
|
| Target Name |
Bacterial Transcriptional regulatory protein (EmbR) |
Target Info |
| Gene Name |
embR |
| Uniprot ID |
EMBR_MYCTU |
| Species |
Mycobacterium tuberculosis |
| Reference Sequence |
MAGSATVEKRLDFGLLGPLQMTIDGTPVPSGTPKQRAVLAMLVINRNRPVGVDALITALW
EEWPPSGARASIHSYVSNLRKLLGGAGIDPRVVLAAAPPGYRLSIPDNTCDLGRFVAEKT
AGVHAAAAGRFEQASRHLSAALREWRGPVLDDLRDFQFVEPFATALVEDKVLAHTAKAEA
EIACGRASAVIAELEALTFEHPYREPLWTQLITAYYLSDRQSDALGAYRRVKTTLADDLG
IDPGPTLRALNERILRQQPLDAKKSAKTTAAGTVTVLDQRTMASGQQAVAYLHDIASGRG
YPLQAAATRIGRLHDNDIVLDSANVSRHHAVIVDTGTNYVINDLRSSNGVHVQHERIRSA
VTLNDGDHIRICDHEFTFQISAGTHGGT [Mycobacterium tuberculosis]
|
| Targeted Disease |
Tuberculosis |
| Drug Resistance Mutations |
| Mutation info |
Missense: Q379R |
[1], [8] |
|
| Mutation info |
Missense: C110Y |
[4], [8] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Intergenic: Minus 273 |
[1] |
|
| Mutation info |
Missense: A176V |
[4] |
| Mutation Frequency |
2 out of 44 isolates |
|
| Mutation info |
Missense: A187V |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: D223E |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: D53H |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: E200A |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: G240R |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: H351E |
[4] |
|
| Mutation info |
Missense: I369T |
[4] |
| Mutation Frequency |
5 out of 44 isolates |
|
| Mutation info |
Missense: I396T |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: L172R |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: L211M |
[4] |
| Mutation Frequency |
2 out of 44 isolates |
|
| Mutation info |
Missense: L292M |
[4] |
|
| Mutation info |
Missense: L303E |
[4] |
|
| Mutation info |
Missense: L320V |
[4] |
| Mutation Frequency |
2 out of 44 isolates |
|
| Mutation info |
Missense: R186G |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: R230W |
[4] |
| Mutation Frequency |
5 out of 44 isolates |
|
| Mutation info |
Missense: R356G |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: S188R |
[4] |
| Mutation Frequency |
3 out of 44 isolates |
|
| Mutation info |
Missense: S326N |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: T32P |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: V350G |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Mutation info |
Missense: V7G |
[4] |
| Mutation Frequency |
1 out of 44 isolates |
|
| Target Name |
Bacterial Probable arabinosyltransferase C (embA) |
Target Info |
| Gene Name |
embA |
| Uniprot ID |
EMBA_MYCTU |
| Species |
Mycobacterium tuberculosis |
| Reference Sequence |
MPHDGNERSHRIARLAAVVSGIAGLLLCGIVPLLPVNQTTATIFWPQGSTADGNITQITA
PLVSGAPRALDISIPCSAIATLPANGGLVLSTLPAGGVDTGKAGLFVRANQDTVVVAFRD
SVAAVAARSTIAAGGCSALHIWADTGGAGADFMGIPGGAGTLPPEKKPQVGGIFTDLKVG
AQPGLSARVDIDTRFITTPGALKKAVMLLGVLAVLVAMVGLAALDRLSRGRTLRDWLTRY
RPRVRVGFASRLADAAVIATLLLWHVIGATSSDDGYLLTVARVAPKAGYVANYYRYFGTT
EAPFDWYTSVLAQLAAVSTAGVWMRLPATLAGIACWLIVSRFVLRRLGPGPGGLASNRVA
VFTAGAVFLSAWLPFNNGLRPEPLIALGVLVTWVLVERSIALGRLAPAAVAIIVATLTAT
LAPQGLIALAPLLTGARAIAQRIRRRRATDGLLAPLAVLAAALSLITVVVFRDQTLATVA
ESARIKYKVGPTIAWYQDFLRYYFLTVESNVEGSMSRRFAVLVLLFCLFGVLFVLLRRGR
VAGLASGPAWRLIGTTAVGLLLLTFTPTKWAVQFGAFAGLAGVLGAVTAFTFARIGLHSR
RNLTLYVTALLFVLAWATSGINGWFYVGNYGVPWYDIQPVIASHPVTSMFLTLSILTGLL
AAWYHFRMDYAGHTEVKDNRRNRILASTPLLVVAVIMVAGEVGSMAKAAVFRYPLYTTAK
ANLTALSTGLSSCAMADDVLAEPDPNAGMLQPVPGQAFGPDGPLGGISPVGFKPEGVGED
LKSDPVVSKPGLVNSDASPNKPNAAITDSAGTAGGKGPVGINGSHAALPFGLDPARTPVM
GSYGENNLAATATSAWYQLPPRSPDRPLVVVSAAGAIWSYKEDGDFIYGQSLKLQWGVTG
PDGRIQPLGQVFPIDIGPQPAWRNLRFPLAWAPPEADVARIVAYDPNLSPEQWFAFTPPR
VPVLESLQRLIGSATPVLMDIATAANFPCQRPFSEHLGIAELPQYRILPDHKQTAASSNL
WQSSSTGGPFLFTQALLRTSTIATYLRGDWYRDWGSVEQYHRLVPADQAPDAVVEEGVIT
VPGWGRPGPIRALP [Mycobacterium tuberculosis]
|
| Targeted Disease |
Tuberculosis |
| Drug Resistance Mutations |
| Mutation info |
Missense: A201T |
[1], [3] |
|
| Mutation info |
Missense: A462V |
[1], [3] |
|
| Mutation info |
Missense: D4N |
[1], [3] |
|
| Mutation info |
Missense: D833A |
[1], [3] |
|
| Mutation info |
Missense: G321S |
[1], [3] |
|
| Mutation info |
Missense: G350D |
[1], [3] |
|
| Mutation info |
Missense: P913S |
[1], [3] |
|
| Mutation info |
Frameshift: Minus 43 |
[1] |
|
| Mutation info |
Missense: G5S |
[3] |
|
| Target Name |
Bacterial dTDP-L-rhamnose synthase (rmlD) |
Target Info |
| Gene Name |
rmlD |
| Uniprot ID |
RMLD_MYCTU |
| Species |
Mycobacterium tuberculosis |
| Reference Sequence |
MAGRSERLVITGAGGQLGSHLTAQAAREGRDMLALTSSQWDITDPAAAERIIRHGDVVIN
CAAYTDVDGAESNEAVAYAVNATGPQHLARACARVGARLIHVSTDYVFDGDFGGAEPRPY
EPTDETAPQGVYARSKLAGEQAVLAAFPEAAVVRTAWVYTGGTGKDFVAVMRRLAAGHGR
VDVVDDQTGSPTYVADLAEALLALADAGVRGRVLHAANEGVVSRFGQARAVFEECGADPQ
RVRPVSSAQFPRPAPRSSYSALSSRQWALAGLTPLRHWRSALATALAAPANSTSIDRRLP
STRD [Mycobacterium tuberculosis]
|
| Targeted Disease |
Tuberculosis |
| Drug Resistance Mutations |
| Mutation info |
Missense: S257P |
[1] |
|
| Target Name |
Bacterial Isoniazid-induced protein (IniB) |
Target Info |
| Gene Name |
iniB |
| Uniprot ID |
INIB_MYCTU |
| Species |
Mycobacterium tuberculosis |
| Reference Sequence |
MTSLIDYILSLFRSEDAARSFVAAPGRAMTSAGLIDIAPHQISSVAANVVPGLNLGAGDP
MSGLRQAVAARHGFAQDVANVGFAGDAGAGVASVITTDVGAGLASGLGAGFLGQGGLALA
ASSGGFGGQVGLAAQVGLGFTAVIEAEVGAQVGAGLGIGTGLGAQAGMGFGGGVGLGLGG
QAGGVIGGSAAGAIGAGVGGRLGGNGQIGVAGQGAVGAGVGAGVGGQAGIASQIGVSAGG
GLGGVGNVSGLTGVSSNAVLASNASGQAGLIASEGAALNGAAMPHLSGPLAGVGVGGQAG
AAGGAGLGFGAVGHPTPQPAALGAAGVVAKTEAAAGVVGGVGGATAAGVGGAHGDILGHE
GAALGSVDTVNAGVTPVEHGLVLPSGPLIHGGTGGYGGMNPPVTDAPAPQVPARAQPMTT
AAEHTPAVTQPQHTPVEPPVHDKPPSHSVFDVGHEPPVTHTPPAPIELPSYGLFGLPGF
[Mycobacterium tuberculosis]
|
| Targeted Disease |
Tuberculosis |
| Drug Resistance Mutations |
| Mutation info |
Missense: A47T |
[1] |
|
| Target Name |
Bacterial D-alpha-D-mannose-1-phosphate guanylyltransferase ManB (rmlA2) |
Target Info |
| Gene Name |
rmlA2 |
| Uniprot ID |
L7N6A5_MYCTU |
| Species |
Mycobacterium tuberculosis |
| Reference Sequence |
MATHQVDAVVLVGGKGTRLRPLTLSAPKPMLPTAGLPFLTHLLSRIAAAGIEHVILGTSY
KPAVFEAEFGDGSALGLQIEYVTEEHPLGTGGGIANVAGKLRNDTAMVFNGDVLSGADLA
QLLDFHRSNRADVTLQLVRVGDPRAFGCVPTDEEDRVVAFLEKTEDPPTDQINAGCYVFE
RNVIDRIPQGREVSVEREVFPALLADGDCKIYGYVDASYWRDMGTPEDFVRGSADLVRGI
APSPALRGHRGEQLVHDGAAVSPGALLIGGTVVGRGAEIGPGTRLDGAVIFDGVRVEAGC
VIERSIIGFGARIGPRALIRDGVIGDGADIGARCELLSGARVWPGVFLPDGGIRYSSDV
[Mycobacterium tuberculosis]
|
| Targeted Disease |
Tuberculosis |
| Drug Resistance Mutations |
| Mutation info |
Missense: D152N |
[1] |
|
| Target Name |
Bacterial Uncharacterized protein (Rv3126c) |
Target Info |
| Gene Name |
Rv3126c |
| Species |
Mycobacterium tuberculosis |
| Targeted Disease |
Tuberculosis |
| Drug Resistance Mutations |
| Mutation info |
Missense: L276R |
[1] |
|
| Target Name |
Bacterial Molybdopterin biosynthesis positive regulator (Rv3124) |
Target Info |
| Gene Name |
Rv3124 |
| Uniprot ID |
MOAR1_MYCTU |
| Species |
Mycobacterium tuberculosis |
| Reference Sequence |
MGQRPFSPNHRSGVLNATTAGAVQFNVLGPLELNLRGTKLPLGTPKQRAVLAMLLLSRNQ
VVAADALVQAIWEKSPPARARRTVHTYICNLRRTLSDAGVDSRNILVSEPPGYRLLIGDR
QQCDLDRFVAAKESGLRASAKGYFSEAIRYLDSALQNWRGPVLGDLRSFMFVQMFSRALT
EDELLVHTKLAEAAIACGRADVVIPKLERLVAMHPYRESLWKQLMLGYYVNEYQSAAIDA
YHRLKSTLAEELGVEPAPTIRALYHKILRQLPMDDLVGRVTRGRVDLRGGNGAKVEELTE
SDKDLLPIGLA [Mycobacterium tuberculosis]
|
| Targeted Disease |
Tuberculosis |
| Drug Resistance Mutations |
| Mutation info |
Intergenic: Minus 16 |
[1] |
|
| Target Name |
Bacterial Conserved protein (Rv0340) |
Target Info |
| Gene Name |
Rv0340 |
| Uniprot ID |
O33270_MYCTU |
| Species |
Mycobacterium tuberculosis |
| Reference Sequence |
MANSLLDFVISLVRDPEAAARYAANPERSIAEAHLTDVTRADVNSLIPVVSDSLSMSEPI
GAAGGAHAGDRGNVWASGAATAALDAFAPHADAGVVQQHGAVGSVLNQPTPPGPGVTPTD
PRPFRAGPHETSALLTSAEIPDTTSEDGGLPTDHPAVWNHPVVDPHTVEPDHHGYDIHG
[Mycobacterium tuberculosis]
|
| Targeted Disease |
Tuberculosis |
| Drug Resistance Mutations |
| Mutation info |
Frameshift: Minus 24 |
[1] |
|
| Mutation info |
Missense: T173M |
[1] |
|
| Target Name |
Bacterial Uncharacterized PPE family protein (PPE49) |
Target Info |
| Gene Name |
Rv3125c |
| Uniprot ID |
PPE49_MYCTU |
| Species |
Mycobacterium tuberculosis |
| Reference Sequence |
MMMMMVLGFSWLPPEINSARMFAGAGSGPLFAAASAWEGLAADLWASASSFESVLAALTT
GPWTGPASMSMAAAASPYVGWLSTVASQAQLAAIQARAAATAFEAALAATVHPTAVTANR
VSLASLIAANVLGQNTPAIAATEFDYLEMWAQDVAAMVGYHAGAKSVAATLAPFSLPPVS
LAGLAAQVGTQVAGMATTASAAVTPVVEGAMASVPTVMSGMQSLVSQLPLQHASMLFLPV
RILTSPITTLASMARESATRLGPPAGGLAAANTPNPSGAAIPAFKPLGGRELGAGMSAGL
GQAQLVGSMSVPPTWQGSIPISMASSAMSGLGVPPNPVALTQAAGAAGGGMPMMLMPMSI
SGAGAGMPGGLMDRDGAGWHVTQARLTVIPRTGVG [Mycobacterium tuberculo
sis]
|
| Targeted Disease |
Tuberculosis |
| Drug Resistance Mutations |
| Mutation info |
Missense: P54S |
[1] |
|
| References |
| REF 1 |
Molecular genetic analysis of nucleotide polymorphisms associated with ethambutol resistance in human isolates of Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2000 Feb;44(2):326-36.
|
| REF 2 |
Nucleotide polymorphism associated with ethambutol resistance in clinical isolates of Mycobacterium tuberculosis. Curr Microbiol. 2006 Nov;53(5):401-5.
|
| REF 3 |
Bioinformatics of antimicrobial resistance in the age of molecular epidemiology. Curr Opin Microbiol. 2015 Oct;27:45-50.
|
| REF 4 |
emb nucleotide polymorphisms and the role of embB306 mutations in Mycobacterium tuberculosis resistance to ethambutol. Int J Med Microbiol. 2009 Apr;299(4):269-80.
|
| REF 5 |
Mutations in the embB locus among Korean clinical isolates of Mycobacterium tuberculosis resistant to ethambutol. Yonsei Med J. 2002 Feb;43(1):59-64.
|
| REF 6 |
Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations. Antimicrob Agents Chemother. 1997 Aug;41(8):1677-81.
|
| REF 7 |
CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573.
|
| REF 8 |
The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57.
|
| REF 9 |
The molecular epidemiology of ethambutol-resistant Mycobacterium tuberculosis in Henan Province, China. Jpn J Infect Dis. 2005 Dec;58(6):393-5.
|
| REF 10 |
Genetic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates in Hong Kong. J Antimicrob Chemother. 2007 May;59(5):866-73.
|
| REF 11 |
Genotypic characterization of drug-resistant Mycobacterium tuberculosis isolates from Peru. Tuber Lung Dis. 1998;79(2):111-8.
|
| REF 12 |
[Surveillance of drug resistant tuberculosis in Hubei, China]. Zhonghua Jie He He Hu Xi Za Zhi. 2002 Dec;25(12):723-6.
|
| REF 13 |
Novel mutations within the embB gene in ethambutol-susceptible clinical isolates of Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2004 Nov;48(11):4447-9.
|
| REF 14 |
Characterisation of rpsL, rrs and embB mutations associated with streptomycin and ethambutol resistance in Mycobacterium tuberculosis. Res Microbiol. 2004 Dec;155(10):830-4.
|
| REF 15 |
Significance of mutations in embB codon 306 for prediction of ethambutol resistance in clinical Mycobacterium tuberculosis isolates. Antimicrob Agents Chemother. 2006 May;50(5):1900-2.
|
