Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00FLT
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| Former ID |
DNC001332
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| Drug Name |
Sinefungin
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| Synonyms |
sinefungin; ADENOSYL-ORNITHINE; Sinefunginum; Sinefungina; Sinefungine; Antibiotic A 9145; Compound 57926; Adenosylornithine; 58944-73-3; A 9145; Antibiotic 32232 RP; Sinefungin [USAN:INN]; Sinefungine [INN-French]; Sinefunginum [INN-Latin]; UNII-W2U467CIIL; Sinefungina [INN-Spanish]; 6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxydecofuranuronic acid; 6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-beta-D-ribo-decofuranuronic acid; BRN 3574678; W2U467CIIL; RP 32232; LY 57926; CHEBI:45453; Decofuranuronic
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H23N7O5
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| Canonical SMILES |
C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)CC(CCC(C(=O)O)N)N)O)O)N
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| InChI |
1S/C15H23N7O5/c16-6(1-2-7(17)15(25)26)3-8-10(23)11(24)14(27-8)22-5-21-9-12(18)19-4-20-13(9)22/h4-8,10-11,14,23-24H,1-3,16-17H2,(H,25,26)(H2,18,19,20)/t6-,7-,8+,10+,11+,14+/m0/s1
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| InChIKey |
LMXOHSDXUQEUSF-YECHIGJVSA-N
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| CAS Number |
CAS 58944-73-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
584821, 819482, 828014, 830209, 7890441, 8189708, 11532841, 14720016, 14853605, 26713189, 43122261, 46391461, 46392974, 46394220, 47170026, 47207507, 49689642, 49693314, 49703988, 49738087, 49960478, 50853899, 56373957, 56385627, 56385642, 57315522, 57646561, 57655016, 87225867, 96026254, 99213276, 99239762, 99376319, 99455796, 104233930, 104240365, 104333832, 115001456, 121360564, 124349591, 124756170, 124767828, 125333104, 131271530, 131271679, 134340532, 134964911, 135023153, 137263938, 152146461
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| ChEBI ID |
CHEBI:45453
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Streptomyces RNA methyltransferase (Stre-myc carB) | Target Info | Inhibitor | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The effect of sinefungin and synthetic analogues on RNA and DNA methyltransferases from Streptomyces. J Antibiot (Tokyo). 1991 Oct;44(10):1141-7. | |||
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