Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01MUR
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| Former ID |
DAP000602
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| Drug Name |
Brinzolamide
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| Synonyms |
Azopt; Birnzolamide; Alcon brand of brinzolamide; Allphar brand of brinzolamide; Brinzolamide [USAN]; AL 4862; AL04862; BZ1; AL-4862; Azopt (TN); Brinzolamide (BRZ); Brinzolamide (JAN/USP/INN); (+)-4-ETHYLAMINO-3,4-DIHYDRO-2-(METHOXY)PROPYL-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE; (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide; (4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide; (R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide 1,1-dioxide; (R)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide; 2H-Thieno(3,2-e)-1,2-thiazine-6-sulfonamide,4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-,1,1-dioxide,R
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| Drug Type |
Small molecular drug
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| Indication | Open-angle glaucoma [ICD-11: 9C61] | Approved | [1], [2] | |
| Therapeutic Class |
Antiglaucomic Agents
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| Company |
Alcon Laboratories
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| Structure |
 |
Download2D MOL |
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| Formula |
C12H21N3O5S3
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| Canonical SMILES |
CCNC1CN(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)CCCOC
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| InChI |
1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1
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| InChIKey |
HCRKCZRJWPKOAR-JTQLQIEISA-N
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| CAS Number |
CAS 138890-62-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9962, 7847718, 7886394, 8192384, 11466393, 11467513, 11486146, 11528766, 12015162, 14780300, 14878101, 26718765, 29214990, 43125358, 46394376, 46507071, 46511455, 47871124, 47871125, 48020430, 48395296, 49699073, 56463043, 57317102, 74925916, 85788886, 87325228, 92125455, 92721410, 92729740, 93166197, 103914463, 104234232, 104343207, 109692908, 117630731, 118048468, 121363126, 124800916, 126627643, 126659540, 126661718, 128041764, 134337893, 135028809, 135916574, 137005796, 143102638, 144204273, 152159683
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| ChEBI ID |
CHEBI:3176
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| ADReCS Drug ID | BADD_D00296 | |||
| SuperDrug ATC ID |
S01EC04
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| SuperDrug CAS ID |
cas=138890627
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Carbonic anhydrase IV (CA-IV) | Target Info | Modulator | [3] |
| KEGG Pathway | Nitrogen metabolism | |||
| Proximal tubule bicarbonate reclamation | ||||
| Reactome | Erythrocytes take up carbon dioxide and release oxygen | |||
| Erythrocytes take up oxygen and release carbon dioxide | ||||
| Reversible hydration of carbon dioxide | ||||
| WikiPathways | Reversible Hydration of Carbon Dioxide | |||
| Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | ||||
| Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6797). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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