Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01QSO
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| Former ID |
DCL001087
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| Drug Name |
Buparlisib
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| Synonyms |
BKM120
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| Drug Type |
Small molecular drug
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| Indication | Breast cancer [ICD-11: 2C60-2C65] | Phase 3 | [1], [2] | |
| Company |
Novartis
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| Structure |
 |
Download2D MOL |
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| Formula |
C18H21F3N6O2
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| Canonical SMILES |
C1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4
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| InChI |
1S/C18H21F3N6O2/c19-18(20,21)13-9-15(22)23-11-12(13)14-10-16(26-1-5-28-6-2-26)25-17(24-14)27-3-7-29-8-4-27/h9-11H,1-8H2,(H2,22,23)
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| InChIKey |
CWHUFRVAEUJCEF-UHFFFAOYSA-N
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| CAS Number |
CAS 944396-07-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
26514721, 30496774, 46552185, 124360790, 125164703, 125748809, 126731451, 131481018, 135257704, 135727430, 136920426, 137275918, 141140538, 144116299, 152258893, 160647741, 160699332, 160778579, 160832406, 160859446, 160962898, 162011605, 162038028, 162202757, 163095481, 163397666, 163638917, 163844284, 164041710, 164193927, 170483801, 174531629, 177749434, 186014842, 189622831, 198945584, 203090396, 204389210, 223366207, 223377786, 223617414, 223685883, 223705058, 224431509, 226513020, 242059886, 247282789, 249794175, 249816445, 249831971
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| ChEBI ID |
CHEBI:71954
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7878). | |||
| REF 2 | ClinicalTrials.gov (NCT01610284) Phase III Study of BKM120/Placebo With Fulvestrant in Postmenopausal Patients With Hormone Receptor Positive HER2-negative Locally Advanced or Metastatic Breast Cancer Refractory to Aromatase Inhibitor. U.S. National Institutes of Health. | |||
| REF 3 | Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009 Aug;8(8):627-44. | |||
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