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| Interaction between the Drug and Microbe |
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| The Metabolism of Drug Affected by Studied Microbe(s) |
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota |
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Studied Microbe: Gut microbiota unspecific
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[3] |
| Resulting Metabolite |
6-thioguanine nucleotides |
| Description |
Thioguanine can be metabolized to 6-thioguanine nucleotides by gut microbiota. |
| Target and Pathway |
Top |
| Target(s) |
Inosine-5'-monophosphate dehydrogenase (IMPDH) |
Target Info
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Intercalator |
[4] |
| References |
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| REF 1 |
URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6845).
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| REF 2 |
Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
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| REF 3 |
Gut microbiota-driven drug metabolism in inflammatory bowel disease. J Crohns Colitis. 2020 Jul 11;15(2):307-15.
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| REF 4 |
Immune effector cells produce lethal DNA damage in cells treated with a thiopurine. Cancer Res. 2009 Mar 15;69(6):2393-9.
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