Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09NMD
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| Former ID |
DAP001445
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| Drug Name |
Lasofoxifene
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| Synonyms |
Oporia; 180916-16-9; rac-Lasofoxifene; CP 336156; Fablyn; UNII-337G83N988; (5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol; CHEMBL328190; 337G83N988; (-)-cis-5,6,7,8-Tetrahydro-6-phenyl-5-(p-(2-(1-pyrrolidinyl)ethoxy)phenyl)-2-naphthol; 180915-78-0; CP-336,156; LASOFOXIFENE HCL; Lasofoxifene [INN:BAN]; AC1L50OI; SCHEMBL26815; GTPL7542; CTK8F1062; BDBM20606; DTXSID50171037; GXESHMAMLJKROZ-IAPPQJPRSA-N; ZINC3918428; BCP03626; AKOS030241621; AN-3516; BCP9000842; DB06202; Oporia; Lasofoxifene [INN]; Cis-1R-(4'-pyrrolidinoethoxyphenyl)-2S-phenyl-6-hydroxy-1,2,3,4-tetrahydronaphthalene, tartrate salt; AZD9639
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| Drug Type |
Small molecular drug
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| Indication | Osteoporosis [ICD-11: FB83.0; ICD-10: M85.8] | Approved | [1], [2] | |
| Virus infection [ICD-11: 1A24-1D9Z] | Discontinued in Phase 1 | [3] | ||
| Company |
Pfizer
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| Structure |
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Download2D MOL |
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| Formula |
C28H31NO2
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| Canonical SMILES |
C1CCN(C1)CCOC2=CC=C(C=C2)C3C(CCC4=C3C=CC(=C4)O)C5=CC=CC=C5
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| InChI |
1S/C28H31NO2/c30-24-11-15-27-23(20-24)10-14-26(21-6-2-1-3-7-21)28(27)22-8-12-25(13-9-22)31-19-18-29-16-4-5-17-29/h1-3,6-9,11-13,15,20,26,28,30H,4-5,10,14,16-19H2/t26-,28+/m1/s1
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| InChIKey |
GXESHMAMLJKROZ-IAPPQJPRSA-N
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| CAS Number |
CAS 180916-16-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9372902, 14831231, 14904412, 24770716, 30420129, 49688680, 50075362, 50359465, 53787068, 57399782, 103314903, 113461635, 126667068, 128019372, 134338645, 134339082, 135136354, 135341628, 136946558, 137115371, 142314011, 144116131, 163125974, 164228137, 164834342, 179150118, 187051843, 198945374, 204370304, 223662242, 223741437, 226414580
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| ChEBI ID |
CHEBI:135938
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| ADReCS Drug ID | BADD_D01250 | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7542). | |||
| REF 2 | Pfizer. Product Development Pipeline. March 31 2009. | |||
| REF 3 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026623) | |||
| REF 4 | Prospects for the development of fusion inhibitors to treat human respiratory syncytial virus infection. Curr Opin Drug Discov Devel. 2009 Jul;12(4):479-87. | |||
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