Drug Information
Drug General Information | Top | |||
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Drug ID |
D09TAB
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Former ID |
DIB008584
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Drug Name |
Pexidartinib
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Synonyms |
PLX-3397
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Indication | Tenosynovial giant cell tumour [ICD-11: 2F7B; ICD-10: D48.0] | Approved | [1] | |
Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Phase 3 | [2] | ||
Pigmented villonodular synovitis [ICD-11: FA27.1; ICD-10: M12.2] | Phase 3 | [3] | ||
Neurofibromatosis type 1 [ICD-11: LD2D.10; ICD-10: Q85.0] | Phase 1/2 | [4] | ||
Company |
Plexxikon Inc
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Structure |
Download2D MOL |
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Formula |
C20H15ClF3N5
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Canonical SMILES |
C1=CC(=NC=C1CC2=CNC3=C2C=C(C=N3)Cl)NCC4=CN=C(C=C4)C(F)(F)F
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InChI |
1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29)
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InChIKey |
JGWRKYUXBBNENE-UHFFFAOYSA-N
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CAS Number |
CAS 1029044-16-3
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PubChem Compound ID | ||||
ChEBI ID |
CHEBI:145373
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ADReCS Drug ID | BADD_D02515 |
References | Top | |||
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REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 | |||
REF 2 | ClinicalTrials.gov (NCT02371369) PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS). U.S. National Institutes of Health. | |||
REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
REF 4 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) |
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