Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0BF8G
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| Former ID |
DAP001021
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| Drug Name |
Pamidronate
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| Synonyms |
AHPrBP; Amidronate; Aminomux; Aminopropanehydroxydiphosphonate; Aredia; Ribodroat; Acide pamidronique; Acido pamidronico; Acidum pamidronicum; Aminohydroxypropylidene diphosphonate; Novartis brand of pamidronate disodium salt; PAMIDRONATE DISODIUM; PAMIDRONIC ACID; Pamidronate calcium; Pamidronate monosodium; Bisphosphonate 6; Acide pamidronique [INN-French]; Acido pamidronico [INN-Spanish]; Acidum pamidronicum [INN-Latin]; Pamidronic acid (INN); Pamidronic acid [INN:BAN]; Ribodroat (TN); Amino-1-hydroxypropane-1,1-diphosphonate; (3-AMINO-1-HYDROXY-1-PHOSPHONO-PROPYL)PHOSPHONIC ACID; (3-Amino-1-hydroxypropylidene)bisphosphonic acid; (3-Amino-1-hydroxypropylidene)diphosphonic acid; (3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid; (3-amino-1-hydroxypropane-1,1-diyl)bis(phosphonic acid); (3-amino-1-hydroxypropylidene)-1,1-biphosphonate; (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate; 1-hydroxy-3-aminopropane-1,1-diphosphonic acid; 3-Amino-1-hydroxypropylidene-1,1-diphosphonate
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| Drug Type |
Small molecular drug
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| Indication | Hypercalcaemia [ICD-11: 5B91.0; ICD-9: 275.42] | Approved | [1], [2] | |
| Therapeutic Class |
Antiinflammatory Agents
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| Structure |
 |
Download2D MOL |
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| Formula |
C3H11NO7P2
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| Canonical SMILES |
C(CN)C(O)(P(=O)(O)O)P(=O)(O)O
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| InChI |
1S/C3H11NO7P2/c4-2-1-3(5,12(6,7)8)13(9,10)11/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11)
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| InChIKey |
WRUUGTRCQOWXEG-UHFFFAOYSA-N
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| CAS Number |
CAS 40391-99-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9599, 634946, 3291059, 5656761, 8152871, 10318359, 11213385, 14798245, 17137002, 25630003, 29215372, 29215373, 29223762, 46504823, 46513038, 47589120, 48416373, 50064771, 50399926, 53790869, 57322390, 85246606, 92217723, 92309049, 93166696, 96024424, 103219240, 104307093, 108146479, 124599993, 125349963, 129624957, 131313809, 131349590, 134338289, 135002241, 135692397, 137004053, 142216111, 144205217, 160963630, 163137156, 163411571, 166219986, 170464689, 175266369, 177012421, 178103833, 179098205, 184546265
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| ChEBI ID |
CHEBI:7903
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| ADReCS Drug ID | BADD_D01661 ; BADD_D01662 | |||
| SuperDrug ATC ID |
M05BA03
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| SuperDrug CAS ID |
cas=040391999
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Geranyltranstransferase (FDPS) | Target Info | Inhibitor | [3] |
| BioCyc | Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) | |||
| Superpathway of cholesterol biosynthesis | ||||
| Trans, trans-farnesyl diphosphate biosynthesis | ||||
| Geranylgeranyldiphosphate biosynthesis | ||||
| KEGG Pathway | Terpenoid backbone biosynthesis | |||
| Metabolic pathways | ||||
| Biosynthesis of antibiotics | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | Cholesterol biosynthesis | |||
| Pathwhiz Pathway | Steroid Biosynthesis | |||
| Reactome | Cholesterol biosynthesis | |||
| Activation of gene expression by SREBF (SREBP) | ||||
| WikiPathways | Activation of Gene Expression by SREBP (SREBF) | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7259). | |||
| REF 2 | Current and future treatments of bone metastases. Expert Opin Emerg Drugs. 2008 Dec;13(4):609-27. | |||
| REF 3 | Detection of nonsterol isoprenoids by HPLC-MS/MS. Anal Biochem. 2008 Dec 1;383(1):18-24. | |||
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