Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0C0ZC
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| Former ID |
DIB006587
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| Drug Name |
AZ-628
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| Synonyms |
Mutant B-Raf Kinase inhibitors, AstraZeneca; Mutant B-Raf (V600E) kinase inhibitors (cancer), AstraZeneca
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Investigative | [1] | |
| Company |
AstraZeneca plc
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| Structure |
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Download2D MOL |
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| Formula |
C27H25N5O2
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| Canonical SMILES |
CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C
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| InChI |
1S/C27H25N5O2/c1-17-8-9-21(31-25(33)18-6-5-7-19(12-18)27(2,3)15-28)14-24(17)30-20-10-11-23-22(13-20)26(34)32(4)16-29-23/h5-14,16,30H,1-4H3,(H,31,33)
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| InChIKey |
ZGBGPEDJXCYQPH-UHFFFAOYSA-N
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| CAS Number |
CAS 878739-06-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
16780810, 23774118, 42843721, 80726812, 135686126, 135686127, 135686148, 135686149, 135727853, 136340160, 136367489, 137275881, 144115650, 152199665, 152258303, 152344360, 160647142, 162011431, 162038224, 162205170, 163417627, 163850216, 164045112, 164147261, 164158897, 172650520, 172912870, 174531163, 177749066, 185990453, 189622866, 198949888, 208265376, 223388119, 223603882, 223704862, 224269247, 230159436, 242060350, 249302653, 252158401, 252160240, 252166684, 252214923, 252303035
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| ChEBI ID |
CHEBI:91354
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8475). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8475). | |||
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