Drug Information
Drug General Information | Top | |||
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Drug ID |
D0E7RI
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Former ID |
DIB019303
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Drug Name |
PMID17556356C1a
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Synonyms |
Inverse agonist; Indole compound 1a; GTPL2833; BDBM22420; DB06833
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
Structure |
Download2D MOL
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Formula |
C23H28N2
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Canonical SMILES |
CC1=CC=C(C=C1)N2C=C(C3=CC=CC=C32)CNCC4CCCCC4
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InChI |
1S/C23H28N2/c1-18-11-13-21(14-12-18)25-17-20(22-9-5-6-10-23(22)25)16-24-15-19-7-3-2-4-8-19/h5-6,9-14,17,19,24H,2-4,7-8,15-16H2,1H3
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InChIKey |
MMIJMYOYKAKQPN-UHFFFAOYSA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Estrogen-related receptor-alpha (ESRRA) | Target Info | Antagonist | [1] |
Reactome | PPARA activates gene expression | |||
Transcriptional activation of mitochondrial biogenesis | ||||
Nuclear Receptor transcription pathway | ||||
WikiPathways | Mitochondrial Gene Expression | |||
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
Nuclear Receptors |
References | Top | |||
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REF 1 | Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism. J Biol Chem. 2007 Aug 10;282(32):23231-9. | |||
REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2833). |
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