Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0N0ES
|
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| Former ID |
DAP001546
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| Drug Name |
Vitamin B3
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| Synonyms |
Niacin (TN); Niacinamide (TN); Nicotinamide (TN)
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|
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| Drug Type |
Small molecular drug
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| Indication | Lipid metabolism disorder [ICD-11: 5C52.Z] | Approved | [1] | |
| Company |
Anmar
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| Structure |
 |
Download2D MOL |
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| Formula |
C6H5NO2
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| Canonical SMILES |
C1=CC(=CN=C1)C(=O)O
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| InChI |
1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
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| InChIKey |
PVNIIMVLHYAWGP-UHFFFAOYSA-N
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| CAS Number |
CAS 59-67-6
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:15940
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Diacylglycerol O-acyltransferase 2 (DGAT2) | Target Info | Inhibitor | [1] |
| Nicotinic acid receptor (HCAR2) | Target Info | Agonist | [1] | |
| BioCyc | Triacylglycerol biosynthesis | |||
| KEGG Pathway | Glycerolipid metabolism | |||
| Metabolic pathways | ||||
| Fat digestion and absorption | ||||
| cAMP signaling pathway | ||||
| Reactome | Acyl chain remodeling of DAG and TAG | |||
| Triglyceride Biosynthesis | ||||
| Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (i) signalling events | ||||
| WikiPathways | Triacylglyceride Synthesis | |||
| Glycerophospholipid biosynthesis | ||||
| Fatty acid, triacylglycerol, and ketone body metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Hakozaki T, Minwalla L, Zhuang J, Chhoa M, Matsubara A, Miyamoto K, Greatens A, Hillebrand GG, Bissett DL, Boissy RE: The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Br J Dermatol. 2002 Jul;147(1):20-31. | |||
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