Drug Information
Drug General Information | Top | |||
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Drug ID |
D0O8UB
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Former ID |
DNCL001944
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Drug Name |
RG7129
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Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Phase 1 | [1] | |
Company |
Roche
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Structure |
Download2D MOL |
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Formula |
C18H14F3N5O2
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Canonical SMILES |
CC1(C(COC(=N1)N)(F)F)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)C#N)F
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InChI |
1S/C18H14F3N5O2/c1-17(18(20,21)9-28-16(23)26-17)12-6-11(3-4-13(12)19)25-15(27)14-5-2-10(7-22)8-24-14/h2-6,8H,9H2,1H3,(H2,23,26)(H,25,27)/t17-/m1/s1
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InChIKey |
DVMUZHLUMHPCGZ-QGZVFWFLSA-N
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CAS Number |
CAS 1310347-50-2
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Beta-secretase (BACE) | Target Info | Modulator | [2] |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT01592331) A Pharmacodynamic and Pharmacokinetic Study of RO5508887 in Healthy Volunteers. U.S. National Institutes of Health. | |||
REF 2 | BACE1 inhibitor drugs in clinical trials for Alzheimer's disease. Alzheimers Res Ther. 2014 Dec 24;6(9):89. |
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