Drug Information
Drug General Information | Top | |||
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Drug ID |
D0RN3S
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Former ID |
DIB004163
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Drug Name |
GS-4997
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Indication | Diabetic nephropathy [ICD-11: GB61.Z; ICD-9: 250.4] | Phase 2 | [1] | |
Pulmonary arterial hypertension [ICD-11: BB01.0; ICD-9: 416] | Phase 2 | [2] | ||
Structure |
Download2D MOL |
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Formula |
C24H24FN7O
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Canonical SMILES |
CC1=CC(=C(C=C1N2C=C(N=C2)C3CC3)C(=O)NC4=CC=CC(=N4)C5=NN=CN5C(C)C)F
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InChI |
1S/C24H24FN7O/c1-14(2)32-13-27-30-23(32)19-5-4-6-22(28-19)29-24(33)17-10-21(15(3)9-18(17)25)31-11-20(26-12-31)16-7-8-16/h4-6,9-14,16H,7-8H2,1-3H3,(H,28,29,33)
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InChIKey |
YIDDLAAKOYYGJG-UHFFFAOYSA-N
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CAS Number |
CAS 1448428-04-3
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PubChem Compound ID |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT02234141) GS-4997 in Adults With Pulmonary Arterial Hypertension. U.S. National Institutes of Health. | |||
REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
REF 3 | Design of a phase 2 clinical trial of an ASK1 inhibitor, GS-4997, in patients with diabetic kidney disease. Nephron. 2015;129(1):29-33. |
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