Drug Information
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides dorei DSM 17855
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| Experimental Method | High-throughput screening | |||
| Description | Ritonavir can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.719; p = 0.006). | |||
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Studied Microbe: Bacteroides eggerthii DSM20697
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[2] | |||
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| Experimental Method | High-throughput screening | |||
| Description | Ritonavir can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -0.627; p = 0.008). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[2] | |||
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| Experimental Method | High-throughput screening | |||
| Description | Ritonavir can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -0.768; p = 0.012). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[2] | |||
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| Experimental Method | High-throughput screening | |||
| Description | Ritonavir can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -0.414; p = 0.048). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[2] | |||
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| Experimental Method | High-throughput screening | |||
| Description | Ritonavir can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -0.652; p = 0.007). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[2] | |||
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| Experimental Method | High-throughput screening | |||
| Description | Ritonavir can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -0.348; p = 0.011). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[2] | |||
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| Experimental Method | High-throughput screening | |||
| Description | Ritonavir can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -0.398; p = 0.018). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[2] | |||
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| Experimental Method | High-throughput screening | |||
| Description | Ritonavir can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.641; p = 0.007). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[2] | |||
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| Experimental Method | High-throughput screening | |||
| Description | Ritonavir can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -0.679; p = 0.031). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[2] | |||
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| Experimental Method | High-throughput screening | |||
| Description | Ritonavir can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -0.603; p = 0.003). | |||
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Studied Microbe: Odoribacter splanchnicus
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[2] | |||
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| Experimental Method | High-throughput screening | |||
| Description | Ritonavir can be metabolized by Odoribacter splanchnicus (log2FC = -0.592; p = 0.008). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[2] | |||
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| Experimental Method | High-throughput screening | |||
| Description | Ritonavir can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -0.387; p = 0.017). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Escherichia coli BW25113
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[2] | |||
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| Experimental Method | High-throughput screening | |||
| Description | Ritonavir can be metabolized by Escherichia coli BW25113 (log2FC = -0.482; p = 0.031). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia hansenii DSM20583
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[2] | |||
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| Experimental Method | High-throughput screening | |||
| Description | Ritonavir can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.636; p = 0.019). | |||
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Studied Microbe: Clostridium sp.
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[2] | |||
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| Experimental Method | High-throughput screening | |||
| Description | Ritonavir can be metabolized by Clostridium sp. (log2FC = -0.518; p = 0.011). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human immunodeficiency virus Protease (HIV PR) | Target Info | Inhibitor | [3], [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 3 | Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV. Int J Antimicrob Agents. 2009 Apr;33(4):307-20. | |||
| REF 4 | Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR. J Biol Chem. 2001 Sep 7;276(36):33309-12. | |||
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