Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00HXX
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| Former ID |
DIB020805
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| Drug Name |
RGFP966
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| Synonyms |
RGFP-966
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C21H19FN4O
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| Canonical SMILES |
C1=CC=C(C=C1)C=CCN2C=C(C=N2)C=CC(=O)NC3=C(C=C(C=C3)F)N
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| InChI |
1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+
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| InChIKey |
BLVQHYHDYFTPDV-VCABWLAWSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:131163
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histone deacetylase 3 (HDAC3) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Thyroid hormone signaling pathway | |||
| Alcoholism | ||||
| Viral carcinogenesis | ||||
| Panther Pathway | Wnt signaling pathway | |||
| Pathway Interaction Database | Signaling events mediated by HDAC Class II | |||
| Signaling events mediated by HDAC Class I | ||||
| Retinoic acid receptors-mediated signaling | ||||
| Validated targets of C-MYC transcriptional repression | ||||
| Regulation of retinoblastoma protein | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2647-52. | |||
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