Drug Information
Drug General Information | Top | |||
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Drug ID |
D00HZV
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Former ID |
DAP001153
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Drug Name |
Trimipramine
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Synonyms |
Sapilent; Stangyl; Surmontil; Surmontyl; Trimeprimina; Trimeprimine; Trimeproprimin; Trimeproprimine; Trimipramina; Trimipraminum; Trimeprimina [Italian]; FI 6120; IL 6001; Beta-Methylimipramine; IL-6001; RP-7162; Rhotrimine (TN); Stangyl (TN); Surmontil (TN); Trimipramina [INN-Spanish]; Trimipraminum [INN-Latin]; Trimipramine (USAN/INN); Trimipramine [USAN:INN:BAN]; Trimipramine, (-)-Isomer; (+)-Trimipramine; (-)-Trimipramine; 1-(3-Dimethylamino-2-methylpropyl)-4,5-dihydro-2,3:6,7-dibenzazepine; 10,11 Dihydro-N,N,beta-trimethyl-5H-dibenz(b,f)azepine-5-propanamine; 10,11-Dihydro-5-(3-dimethylamino-2-methylpropyl)-5H-dibenz(b,f)azepine; 10,11-dihydro-N,N,beta-trimethyl-5H-dibenz[b,f]azepine-5-propanamine; 2'-Metil-3'-dimetilamino-propil-5-iminodibenzile; 2'-Metil-3'-dimetilamino-propil-5-iminodibenzile [Italian]; 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2-trimethylpropan-1-amine; 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N,2-trimethylpropan-1-amine; 5-(3-(Dimethylamino)-2-methylpropyl)-10,11-dihydro-5H-dibenz(b,f)azepine; 5-(gamma-Dimethylamino-beta-methylpropyl)-10,11-dihydro-5H-dibenzo(b,f)azepine; 5-(gamma-dimethylamino-beta-methylpropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine; 5-[3-(dimethylamino)-2-methylpropyl]-10,11-dihydro-5H-dibenz[b,f]azepine; 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N,beta-trimethyl-, (+)-(9CI); 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N,beta-trimethyl-, (-)-(9CI); 7162 RP
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Drug Type |
Small molecular drug
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Indication | Major depressive disorder [ICD-11: 6A70.3; ICD-10: F32.2] | Approved | [1] | |
Therapeutic Class |
Antidepressants
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Company |
Odyssey Pharmaceuticals Inc
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Structure |
Download2D MOL |
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Formula |
C20H26N2
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Canonical SMILES |
CC(CN1C2=CC=CC=C2CCC3=CC=CC=C31)CN(C)C
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InChI |
1S/C20H26N2/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22/h4-11,16H,12-15H2,1-3H3
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InChIKey |
ZSCDBOWYZJWBIY-UHFFFAOYSA-N
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CAS Number |
CAS 3564-75-8
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PubChem Compound ID | ||||
PubChem Substance ID |
4752050, 7847460, 7980837, 8153438, 10534352, 11335268, 11360507, 11364316, 11366878, 11369440, 11372300, 11374257, 11377602, 11461479, 11466834, 11467954, 11485056, 11486328, 11489346, 11490966, 11492574, 11495236, 14751475, 29214834, 29224622, 46507121, 47216629, 47365025, 47515163, 47588839, 47810599, 47959573, 48034950, 48259062, 48334324, 48416674, 49698932, 49761600, 49961515, 49961516, 49961517, 50111256, 57322857, 78776395, 85209670, 85789363, 90341093, 92714629, 92729770, 103189045
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ChEBI ID |
CHEBI:9738
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ADReCS Drug ID | BADD_D02294 ; BADD_D02295 | |||
SuperDrug ATC ID |
N06AA06
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SuperDrug CAS ID |
cas=000739719
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Target and Pathway | Top | |||
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Target(s) | Norepinephrine transporter (NET) | Target Info | Inhibitor | [2] |
Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
WikiPathways | Monoamine Transport | |||
NRF2 pathway | ||||
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
References | Top | |||
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REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
REF 2 | Antidepressants suppress production of the Th1 cytokine interferon-gamma, independent of monoamine transporter blockade. Eur Neuropsychopharmacol. 2006 Oct;16(7):481-90. |
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