Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00KIK
|
|||
| Former ID |
DNC012289
|
|||
| Drug Name |
1-(1-Benzo[b]thiophen-2-yl-cyclohexyl)-azepane
|
|||
| Synonyms |
CHEMBL17945; 1-[1-(1-benzothiophen-2-yl)cyclohexyl]azepane; NCI60_038332; AC1L9GGF; 1-(1-Benzo[b]thiophen-2-yl-cyclohexyl)-azepane; CTK5J7197; QDGRJLAJZNWVGV-UHFFFAOYSA-N; BDBM50040192; 1-[1-(1-Benzothien-2-yl)cyclohexyl]azepane #; Thionaphthene, 2-[1-(1-azacycloheptyl)cyclohexyl]-
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C20H27NS
|
|||
| Canonical SMILES |
C1CCCN(CC1)C2(CCCCC2)C3=CC4=CC=CC=C4S3
|
|||
| InChI |
1S/C20H27NS/c1-2-9-15-21(14-8-1)20(12-6-3-7-13-20)19-16-17-10-4-5-11-18(17)22-19/h4-5,10-11,16H,1-3,6-9,12-15H2
|
|||
| InChIKey |
QDGRJLAJZNWVGV-UHFFFAOYSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dopamine transporter (DAT) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Dopaminergic synapse | |||
| Parkinson's disease | ||||
| Cocaine addiction | ||||
| Amphetamine addiction | ||||
| Alcoholism | ||||
| Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
| Parkinson disease | ||||
| Dopamine receptor mediated signaling pathway | ||||
| Pathway Interaction Database | Alpha-synuclein signaling | |||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
| WikiPathways | Monoamine Transport | |||
| NRF2 pathway | ||||
| Dopaminergic Neurogenesis | ||||
| Parkinsons Disease Pathway | ||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||||
| Neurotransmitter Clearance In The Synaptic Cleft | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and biological evaluation of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-bin... J Med Chem. 1993 Apr 30;36(9):1188-93. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.