Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00UEQ
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| Former ID |
DNC000630
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| Drug Name |
Etomoxir
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| Synonyms |
ETOMOXIR; 82258-36-4; rac- Etomoxir; Etomoxirum [Latin]; Ethyl 2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylate; BRN 4496620; Oxiranecarboxylic acid, 2-(6-(4-chlorophenoxy)hexyl)-, ethyl ester; B 807-54; Ethyl 2-(6-(4-chlorophenoxy)hexyl)oxiranecarboxylate; Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester- [CAS]; Etomoxirum; etomoxir[inn]; SMR000449321; Rac-Etomoxir Ethyl Ester; C17H23ClO4; ethyl 2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate; etoxomir; AC1L3XCY; MLS001424024; MLS000758228; SCHEMBL681359
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| Drug Type |
Small molecular drug
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| Indication | Heart failure [ICD-11: BD10-BD13; ICD-10: I50, I50.9; ICD-9: 428] | Terminated | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C17H23ClO4
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| Canonical SMILES |
CCOC(=O)C1(CO1)CCCCCCOC2=CC=C(C=C2)Cl
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| InChI |
1S/C17H23ClO4/c1-2-20-16(19)17(13-22-17)11-5-3-4-6-12-21-15-9-7-14(18)8-10-15/h7-10H,2-6,11-13H2,1H3/t17-/m1/s1
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| InChIKey |
DZLOHEOHWICNIL-QGZVFWFLSA-N
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| CAS Number |
CAS 124083-20-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
6070434, 10240872, 14777309, 26719759, 29304010, 46386895, 49681665, 50002002, 53642310, 87692428, 92308531, 103824883, 104419407, 117577956, 124658837, 124953656, 124958351, 126435320, 127809295, 135078811, 138845576, 141768074, 162022285, 162262944, 162726096, 172080203, 179295904, 179322899, 226975899, 241163461, 252349776
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| ChEBI ID |
CHEBI:95011
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Carnitine O-palmitoyltransferase I (CPT1B) | Target Info | Modulator | [1] |
| KEGG Pathway | Fatty acid degradation | |||
| Fatty acid metabolism | ||||
| PPAR signaling pathway | ||||
| AMPK signaling pathway | ||||
| Adipocytokine signaling pathway | ||||
| Glucagon signaling pathway | ||||
| Pathwhiz Pathway | Fatty acid Metabolism | |||
| Reactome | RORA activates gene expression | |||
| PPARA activates gene expression | ||||
| Import of palmitoyl-CoA into the mitochondrial matrix | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Mitochondrial LC-Fatty Acid Beta-Oxidation | ||||
| Nuclear Receptors Meta-Pathway | ||||
| PPAR Alpha Pathway | ||||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
| Circadian Clock | ||||
| Fatty Acid Beta Oxidation | ||||
| AMPK Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine. Circ Res. 1988 Dec;63(6):1036-43. | |||
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