Drug Information
Drug General Information | Top | |||
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Drug ID |
D00UVU
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Former ID |
DIB004152
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Drug Name |
Lipoteichoic acid
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Synonyms |
Oncomycin; Lipoteichoic acid (cancer); Lipoteichoic acid (cancer), Lunamed; TLR-2 modulator (subcutaneous, solid tumor), LUNAMeD; Toll like receptor-2 modulator (subcutaneous, solid tumor), LUNAMeD
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Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1/2 | [1] | |
Company |
Lunamed Operations AG
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Structure |
Download2D MOL
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Formula |
C39H70N2O13
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Canonical SMILES |
CCCCCCCC=CCCCCCC(=O)OC(COC1C(C(C(C(O1)CO)O)OC2C(C(C(C(O2)C)N)O)NC(=O)C)O)COC(=O)CCCCCC
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InChI |
1S/C39H70N2O13/c1-5-7-9-11-12-13-14-15-16-17-18-20-22-31(45)52-28(24-49-30(44)21-19-10-8-6-2)25-50-39-36(48)37(34(46)29(23-42)53-39)54-38-33(41-27(4)43)35(47)32(40)26(3)51-38/h14-15,26,28-29,32-39,42,46-48H,5-13,16-25,40H2,1-4H3,(H,41,43)/b15-14+/t26-,28-,29-,32+,33-,34-,35+,36-,37+,38+,39+/m1/s1
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InChIKey |
PANDRCFROUDETH-YLSOAJEOSA-N
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CAS Number |
CAS 56411-57-5
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Toll-like receptor 2 (TLR2) | Target Info | Modulator | [2] |
KEGG Pathway | Phagosome | |||
PI3K-Akt signaling pathway | ||||
Toll-like receptor signaling pathway | ||||
Legionellosis | ||||
Leishmaniasis | ||||
Chagas disease (American trypanosomiasis) | ||||
Malaria | ||||
Toxoplasmosis | ||||
Amoebiasis | ||||
Tuberculosis | ||||
Hepatitis B | ||||
Measles | ||||
Herpes simplex infection | ||||
Proteoglycans in cancer | ||||
Inflammatory bowel disease (IBD) | ||||
Rheumatoid arthritis | ||||
NetPath Pathway | IL4 Signaling Pathway | |||
TCR Signaling Pathway | ||||
Panther Pathway | Toll receptor signaling pathway | |||
Pathway Interaction Database | Endogenous TLR signaling | |||
Reactome | Beta defensins | |||
MyD88:Mal cascade initiated on plasma membrane | ||||
Toll Like Receptor TLR6:TLR2 Cascade | ||||
MyD88 deficiency (TLR2/4) | ||||
IRAK4 deficiency (TLR2/4) | ||||
WikiPathways | Toll-like receptor signaling pathway | |||
IL1 and megakaryotyces in obesity | ||||
Human Complement System | ||||
Toll-Like Receptors Cascades | ||||
MyD88:Mal cascade initiated on plasma membrane | ||||
Defensins | ||||
Regulation of toll-like receptor signaling pathway |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024869) | |||
REF 2 | Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccha... J Biol Chem. 2003 May 2;278(18):15587-94. |
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