Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00VNH
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| Former ID |
DNC014630
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| Drug Name |
ZK-200775
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| Synonyms |
Fanapanel; MPQX; 161605-73-8; ZK 200775; ZK200775; Fanapanel [INN]; UNII-E3AP71EM0O; ZK-200775; E3AP71EM0O; NCGC00159553-01; [7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-4H-quinoxalin-1-yl]methylphosphonic acid; DSSTox_RID_81332; DSSTox_CID_26093; DSSTox_GSID_46093; ((3,4-Dihydro-7-morpholino-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl)methyl)phosphonic acid; {[7-Morpholin-4-Yl-2,3-Dioxo-6-(Trifluoromethyl)-3,4-Dihydroquinoxalin-1(2h)-Yl]methyl}phosphonic Acid; CAS-161605-73-8; C14H15F3N3O6P; ZK1; AC1L4LOG; AC1Q6RR4
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| Drug Type |
Small molecular drug
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| Indication | Coronary artery disease [ICD-11: BA80; ICD-10: I25.1, I25.4] | Phase 1 | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C14H15F3N3O6P
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| Canonical SMILES |
C1COCCN1C2=CC3=C(C=C2C(F)(F)F)NC(=O)C(=O)N3CP(=O)(O)O
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| InChI |
1S/C14H15F3N3O6P/c15-14(16,17)8-5-9-11(6-10(8)19-1-3-26-4-2-19)20(7-27(23,24)25)13(22)12(21)18-9/h5-6H,1-4,7H2,(H,18,21)(H2,23,24,25)
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| InChIKey |
WZMQMKNCWDCCMT-UHFFFAOYSA-N
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| CAS Number |
CAS 161605-73-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9368758, 14806271, 29215531, 30413591, 50067808, 52020190, 57399573, 85756762, 85786999, 103086264, 103150048, 103184959, 113442193, 117626692, 134351835, 135183466, 135698626, 135745722, 140862569, 141003653, 144205298, 162023352, 162799219, 163782383, 170466123, 179322906, 196680101, 198967209, 223365971, 226392887, 226687302, 241375895, 249617549, 252156459, 252481672
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glutamate receptor AMPA (GRIA) | Target Info | Inhibitor | [3] |
| References | Top | |||
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| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7636). | |||
| REF 2 | The AMPA antagonist ZK 200775 in patients with acute ischaemic stroke: a double-blind, multicentre, placebo-controlled safety and tolerability study. Cerebrovasc Dis. 2005;20(5):304-9. | |||
| REF 3 | Synthesis of anticonvulsive AMPA antagonists: 4-oxo-10-substituted-imidaz. Bioorg Med Chem Lett. 2001 May 7;11(9):1205-10. | |||
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