Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D01GFX
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| Former ID |
DNC010680
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| Drug Name |
OSI-906
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| Synonyms |
Linsitinib; 867160-71-2; OSI-906; Linsitinib(OSI-906); OSI906; OSI 906; OSI-906AA; OSI-906 (Linsitinib); UNII-15A52GPT8T; Kinome_3532; ASP-7487; 3-[8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutan-1-ol; 15A52GPT8T; CHEMBL1091644; MMV676605; cis-3-[8-Amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol; C26H23N5O; cis-3-(8-amino-1-(2-phenyl-7-quinolinyl)imidazo(1,5-a)pyrazin-3-yl)-1-methylcyclobutanol; Linsitinib [USAN:INN]; OSI906/Linsitinib/; Linsitinib; OSI-906
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 3 | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C26H23N5O
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| Canonical SMILES |
CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O
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| InChI |
1S/C26H23N5O/c1-26(32)14-19(15-26)25-30-22(23-24(27)28-11-12-31(23)25)18-8-7-17-9-10-20(29-21(17)13-18)16-5-3-2-4-6-16/h2-13,19,32H,14-15H2,1H3,(H2,27,28)
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| InChIKey |
PKCDDUHJAFVJJB-UHFFFAOYSA-N
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| CAS Number |
CAS 867160-71-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
16743657, 23744765, 57275263, 74532058, 103749228, 103905463, 104150248, 131480754, 134347885, 135262588, 135626662, 136340263, 136350036, 136367290, 136367850, 137275876, 137553219, 137553254, 137553468, 144116323, 152258112, 152344419, 160646951, 162011565, 162038063, 162202653, 164041951, 170500763, 174531077, 177748835, 178103995, 180416100, 184816222, 189024767, 196408579, 198945656, 223704703, 226728959, 226729306, 226729307, 235565420, 241383573, 242533722, 242845726, 243364150, 244256025, 247345853, 252160378, 252215970, 252440138
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| ChEBI ID |
CHEBI:91402
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7423). | |||
| REF 2 | ClinicalTrials.gov (NCT00924989) A Study of OSI-906 in Patients With Locally Advanced or Metastatic Adrenocortical Carcinoma. U.S. National Institutes of Health. | |||
| REF 3 | Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family... Bioorg Med Chem Lett. 2010 Apr 15;20(8):2452-5. | |||
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