Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01OHD
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| Former ID |
DIB003006
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| Drug Name |
AMXT-1501
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| Synonyms |
Difluoromethylornithine + polyamine transport inhibitors (head and neck cancer), Aminex Therapeutics; Polyamine transport inhibitors + polyamine biosynthesis inhibitor (head and neck cancer), Aminex Therapeutics/MediQuest Therapeutics; MQT-1426 + DFMO (head and neck cancer), Aminex Therapeutics/MediQuest Therapeutics; Polyamine-based therapy (head and neck-squamous cell carcinoma), Aminex Therapeutics/MediQuest Therapeutics
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| Indication | Head and neck cancer [ICD-11: 2D42] | Investigative | [1] | |
| Company |
MediQuest Therapeutics Inc
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Ornithine decarboxylase (ODC1) | Target Info | Inhibitor | [1] |
| BioCyc | Putrescine biosynthesis I | |||
| NetPath Pathway | TCR Signaling Pathway | |||
| IL2 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| Panther Pathway | Ornithine degradation | |||
| CCKR signaling map ST | ||||
| Pathwhiz Pathway | Spermidine and Spermine Biosynthesis | |||
| Pathway Interaction Database | Validated targets of C-MYC transcriptional activation | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1276). | |||
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