Drug Information
Drug General Information | Top | |||
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Drug ID |
D01WKZ
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Drug Name |
Citarinostat
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Synonyms |
ACY-241; 1316215-12-9; HDAC-IN-2; 2-((2-Chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide; UNII-441P620G3P; 441P620G3P; Citarinostat [USAN]; Citarinostat (USAN); 2-(N-(2-chlorophenyl)anilino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide; 2-((2-Chlorophenyl)phenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)-5-pyrimidinecarboxamide; 2-[(2-Chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide; Citarinostat (ACY-241); SCHEMBL2225863; GTPL942
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Indication | Multiple myeloma [ICD-11: 2A83; ICD-10: C90.0] | Phase 1 | [1] | |
Company |
Celgene Summit, NJ
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Structure |
Download2D MOL |
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Formula |
C24H26ClN5O3
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Canonical SMILES |
C1=CC=C(C=C1)N(C2=CC=CC=C2Cl)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO
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InChI |
1S/C24H26ClN5O3/c25-20-12-7-8-13-21(20)30(19-10-4-3-5-11-19)24-27-16-18(17-28-24)23(32)26-15-9-2-1-6-14-22(31)29-33/h3-5,7-8,10-13,16-17,33H,1-2,6,9,14-15H2,(H,26,32)(H,29,31)
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InChIKey |
VLIUIBXPEDFJRF-UHFFFAOYSA-N
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CAS Number |
CAS 1316215-12-9
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Histone deacetylase 6 (HDAC6) | Target Info | Inhibitor | [1] |
KEGG Pathway | Alcoholism | |||
Viral carcinogenesis | ||||
Pathway Interaction Database | Signaling events mediated by HDAC Class II | |||
Signaling events mediated by HDAC Class I | ||||
Reactome | NOTCH1 Intracellular Domain Regulates Transcription | |||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Assembly of the primary cilium | ||||
WikiPathways | Ectoderm Differentiation | |||
Neural Crest Differentiation | ||||
Cell Cycle |
References | Top | |||
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REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) |
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