Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01WMW
|
|||
| Former ID |
DNCL001799
|
|||
| Drug Name |
RG7232
|
|||
| Indication | Dyslipidemia [ICD-11: 5C80-5C81; ICD-9: 272] | Investigative | [1] | |
| Company |
Roche
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | ATP-binding cassette transporter A1 (ABCA1) | Target Info | Modulator | [1] |
| KEGG Pathway | ABC transporters | |||
| Fat digestion and absorption | ||||
| NetPath Pathway | Leptin Signaling Pathway | |||
| Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | |||
| Reactome | HDL-mediated lipid transport | |||
| PPARA activates gene expression | ||||
| WikiPathways | Statin Pathway | |||
| Nuclear Receptors in Lipid Metabolism and Toxicity | ||||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
| Lipid digestion, mobilization, and transport | ||||
| SREBF and miR33 in cholesterol and lipid homeostasis | ||||
| Folate Metabolism | ||||
| Vitamin B12 Metabolism | ||||
| Selenium Micronutrient Network | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Analysis of "On/Off" Kinetics of a CETP Inhibitor Using a Mechanistic Model of Lipoprotein Metabolism and Kinetics. CPT Pharmacometrics Syst Pharmacol. 2015 Aug;4(8):465-73. | |||
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