Drug Information
Drug General Information | Top | |||
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Drug ID |
D02IJA
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Former ID |
DIB009986
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Drug Name |
Tau-binding PET tracer
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Synonyms |
T-777; T-807; T-808; Tau-binding PET tracer (Alzheimer disease); Tau-binding PET tracer (Alzheimer disease), Siemens
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Drug Type |
Small molecular drug
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Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Phase 2 | [1] | |
Company |
Siemens Medical Solutions Molecular Imaging
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Structure |
Download2D MOL |
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Formula |
C16H10FN3
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Canonical SMILES |
C1=CC2=C(C=C1C3=CN=C(C=C3)F)NC4=C2C=NC=C4
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InChI |
1S/C16H10FN3/c17-16-4-2-11(8-19-16)10-1-3-12-13-9-18-6-5-14(13)20-15(12)7-10/h1-9,20H
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InChIKey |
GETAAWDSFUCLBS-UHFFFAOYSA-N
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CAS Number |
CAS 1415379-56-4
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Microtubule-associated protein tau (MAPT) | Target Info | Modulator | [2] |
KEGG Pathway | MAPK signaling pathway | |||
Alzheimer's disease | ||||
NetPath Pathway | IL2 Signaling Pathway | |||
EGFR1 Signaling Pathway | ||||
Pathway Interaction Database | LPA receptor mediated events | |||
Reelin signaling pathway | ||||
Reactome | Caspase-mediated cleavage of cytoskeletal proteins | |||
WikiPathways | Notch Signaling Pathway | |||
IL-2 Signaling Pathway | ||||
MAPK Signaling Pathway | ||||
Copper homeostasis | ||||
Kit receptor signaling pathway | ||||
BDNF signaling pathway | ||||
Integrated Pancreatic Cancer Pathway | ||||
Alzheimers Disease | ||||
Regulation of Microtubule Cytoskeleton | ||||
Apoptotic execution phase | ||||
IL-5 Signaling Pathway |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT02414347) F 18 T807 Tau PET Imaging of Alzheimer's Disease. U.S. National Institutes of Health. | |||
REF 2 | Microtubules (tau) as an emerging therapeutic target: NAP (davunetide). Curr Pharm Des. 2011;17(31):3413-7. |
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