Drug Information
Drug General Information | Top | |||
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Drug ID |
D02MAK
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Former ID |
DNC011346
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Drug Name |
6-Acetyl-7-hydroxy-2H-chromen-2-one
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Synonyms |
CHEMBL1288534; 6-Acetyl-7-hydroxy-2H-1-benzopyran-2-one; 6835-55-8; 6-Acetyl-7-hydroxy-2H-chromen-2-one; AC1NWHPN; 6-acetyl-7-hydroxycoumarin; 2H-1-Benzopyran-2-one, 6-acetyl-7-hydroxy-; SCHEMBL4640781; 6-acetyl-7-hydroxychromen-2-one; ZINC3848612; BDBM50332033
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C11H8O4
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Canonical SMILES |
CC(=O)C1=C(C=C2C(=C1)C=CC(=O)O2)O
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InChI |
1S/C11H8O4/c1-6(12)8-4-7-2-3-11(14)15-10(7)5-9(8)13/h2-5,13H,1H3
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InChIKey |
MYJIZBGGFRMXEM-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Carbonic anhydrase IX (CA-IX) | Target Info | Inhibitor | [1] |
KEGG Pathway | Nitrogen metabolism | |||
Pathway Interaction Database | HIF-1-alpha transcription factor network | |||
Reactome | Regulation of gene expression by Hypoxia-inducible Factor | |||
Reversible hydration of carbon dioxide | ||||
WikiPathways | Vitamin D Receptor Pathway | |||
Reversible Hydration of Carbon Dioxide | ||||
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
References | Top | |||
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REF 1 | 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. |
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