Drug Information
Drug General Information | Top | |||
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Drug ID |
D02ONP
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Former ID |
DNC010005
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Drug Name |
Ethyl Bis(4-hydroxy-2-oxo-2H-chromen-3-yl)acetate
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Synonyms |
CHEMBL571926
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C21H14O8
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Canonical SMILES |
COC(=O)C(C1=C(C2=CC=CC=C2OC1=O)O)C3=C(C4=CC=CC=C4OC3=O)O
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InChI |
1S/C21H14O8/c1-27-19(24)14(15-17(22)10-6-2-4-8-12(10)28-20(15)25)16-18(23)11-7-3-5-9-13(11)29-21(16)26/h2-9,14,22-23H,1H3
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InChIKey |
XCIPOAZOZKLEOW-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Quinone reductase 1 (NQO1) | Target Info | Inhibitor | [1] |
KEGG Pathway | Ubiquinone and other terpenoid-quinone biosynthesis | |||
NetPath Pathway | TCR Signaling Pathway | |||
Pathwhiz Pathway | Vitamin K Metabolism | |||
Pathway Interaction Database | Validated transcriptional targets of TAp63 isoforms | |||
WikiPathways | Estrogen metabolism | |||
Oxidative Stress | ||||
Transcriptional activation by NRF2 | ||||
NRF2 pathway | ||||
Nuclear Receptors Meta-Pathway | ||||
Aryl Hydrocarbon Receptor Pathway | ||||
Apoptosis-related network due to altered Notch3 in ovarian cancer | ||||
Metabolism of amino acids and derivatives | ||||
Aryl Hydrocarbon Receptor | ||||
Dopamine metabolism | ||||
Arylhydrocarbon receptor (AhR) signaling pathway |
References | Top | |||
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REF 1 | Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J Med Chem. 2009 Nov 26;52(22):7142-56. |
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